ZC3H7A Activators
ZC3H7A activators primarily function by influencing cellular pathways that intersect with ZC3H7A's role, particularly in RNA processing and cellular signaling. Chemicals like LY294002 and Wortmannin target the PI3K/Akt pathway, creating an environment where ZC3H7A's role can become more accentuated. Inhibition of this pathway can reorganize the cellular signaling landscape, allowing for the indirect activation of ZC3H7A through other intersecting pathways. On the other hand, chemicals like Calyculin A and Okadaic Acid act as phosphatase inhibitors and work on a different mechanism. These chemicals can affect the phosphorylation status of several RNA-binding proteins, thereby influencing ZC3H7A's interaction network and possibly its activity.
By affecting diverse cellular pathways, these compounds can bring about shifts in the cellular context where ZC3H7A operates. For instance, MEK inhibitors such as PD98059 and U0126, by modulating the ERK1/2 signaling, can alter RNA splicing processes and therefore indirectly influence ZC3H7A. Meanwhile, compounds like BAPTA-AM and Ionomycin focus on calcium homeostasis, which has a far-reaching impact on RNA-binding proteins and, by extension, on ZC3H7A's functional profile. These compounds serve to adjust the cellular machinery in a way that could make ZC3H7A more functionally dominant in the specified pathways.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that restrains Akt pathway. The Akt pathway converges on several downstream proteins that regulate transcription, and its inhibition reallocates cellular activity to enhance ZC3H7A activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that modulates ERK1/2 signaling. ZC3H7A is implicated in RNA splicing; reduced ERK signaling can lead to shifts in spliceosome assembly, indirectly influencing ZC3H7A. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
PP1 and PP2A phosphatase inhibitor. Phosphatase inhibition can alter the phosphorylation status of RNA-binding proteins, affecting the functional environment in which ZC3H7A operates. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor. Affects stress signaling, which can lead to the modification of ZC3H7A-related RNA-processing activities. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
Intracellular calcium chelator that influences calcium-dependent enzymes, indirectly affecting the regulatory machinery that interacts with ZC3H7A. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor. Similar to LY294002, Wortmannin shifts the cellular signaling landscape, potentially channeling activity to ZC3H7A-regulated pathways. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $133.00 | 20 | |
CaMKII inhibitor that impacts Ca2+ signaling, which can have downstream effects on RNA processing mechanisms where ZC3H7A is active. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
AMPK activator. AMPK is involved in cellular energy regulation, and its activation can shift the energy landscape to promote activities where ZC3H7A is integral. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
PP2A inhibitor. Inhibition of PP2A can lead to a shift in the cellular phosphorylation profile, indirectly enhancing ZC3H7A activity by altering its interaction network. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Calcium ionophore affecting Ca2+ homeostasis. Altered calcium signaling can modify the RNA-binding landscape, potentially favoring ZC3H7A activity. | ||||||