Xg Activators
Xg glycoprotein activators engage in diverse mechanisms to upregulate its activity, primarily through post-translational modifications and signaling pathway interactions. Phosphorylation plays a significant role, as certain activators inhibit phosphatases, thereby maintaining or enhancing phosphorylated states of either the Xg glycoprotein itself or proteins that form part of its signaling nexus. This results in sustained or enhanced functional activity of the Xg glycoprotein. Other activators increase intracellular cAMP or calcium levels, leading to the activation of protein kinases such as PKA or calcium-dependent kinases. These kinases can directly phosphorylate the Xg glycoprotein or adjust the activity of its associated proteins, thereby modulating the activity of Xg glycoprotein indirectly.
Some compounds exert their effects by inhibiting key enzymes like GSK-3β or PI3K, which leads to the activation of alternative signaling pathways that can also result in the post-translational modification of the Xg glycoprotein, altering its activity status. Additionally, activators can induce the activation of AMPK or engage in modulation of multiple signaling pathways like MAPK, PI3K, NF-κB, and STAT3, which are known to be involved in complex cellular responses. These pathways, upon activation, may influence the functional activity of the Xg glycoprotein by altering the phosphorylation landscape of the cellular proteome, including potentially the Xg glycoprotein or its close interactors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Elevates intracellular cAMP levels, thereby activating PKA which can phosphorylate Xg glycoprotein or proteins that associate with Xg, enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-selective inhibitor of phosphodiesterases, increasing cAMP levels and promoting PKA activation which can lead to Xg glycoprotein activation. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Inhibits protein tyrosine phosphatases, potentially enhancing tyrosine phosphorylation on Xg glycoprotein or associated signaling molecules, leading to increased Xg activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC) which could phosphorylate Xg glycoprotein or modulate its associated signaling pathways, increasing Xg activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium concentration, potentially activating calcium-dependent protein kinases that could phosphorylate Xg glycoprotein, increasing its activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β leading to activation of Wnt signaling pathway, which might result in post-translational modifications of Xg glycoprotein, enhancing its functional activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Inhibits protein phosphatases PP1 and PP2A, potentially increasing phosphorylation levels of Xg glycoprotein or proteins within its signaling network, enhancing its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, altering downstream AKT signaling which could lead to the activation of Xg glycoprotein through post-translational modifications or interaction with AKT-regulated pathways. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
Activates AMPK, which could lead to phosphorylation and activation of Xg glycoprotein or proteins in the AMPK signaling pathway influencing Xg activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Inhibits PP1 and PP2A phosphatases, potentially enhancing the phosphorylation of Xg glycoprotein or proteins in related pathways, leading to increased Xg activity. | ||||||