XAGE1E Inhibitors
The chemical class of XAGE1E inhibitors comprises diverse compounds that target various signaling pathways and cellular processes implicated in the regulation of XAGE1E expression and activity. XAGE1E is a cancer-testis antigen associated with tumorigenesis and cancer progression.
One group of inhibitors includes those targeting signaling pathways involved in cell survival, proliferation, and growth, such as the PI3K/AKT/mTOR pathway. Compounds like Wortmannin and Rapamycin inhibit PI3K and mTOR, respectively, leading to downstream effects on protein synthesis and cell growth, potentially suppressing XAGE1E expression by modulating cellular proliferation and survival pathways.
Another class of inhibitors includes those targeting stress response pathways, such as MAPK and HSP90. Compounds like SB203580 and 17-AAG inhibit MAPK and disrupt HSP90 chaperone function, respectively, potentially influencing XAGE1E expression by modulating downstream signaling events involved in cellular stress responses and protein folding.
Furthermore, inhibitors targeting kinase enzymes, such as Src and ROCK, modulate signaling cascades involved in cellular proliferation and survival, potentially impacting XAGE1E expression through downstream signaling events. Collectively, the chemical class of XAGE1E inhibitors provides valuable tools for investigating the molecular mechanisms underlying XAGE1E function.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a multi-kinase inhibitor that targets Raf kinases and inhibits angiogenesis by targeting vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR), potentially suppressing XAGE1E expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 mitogen-activated protein kinase (MAPK) inhibitor that suppresses p38 MAPK signaling, potentially influencing XAGE1E expression by modulating downstream transcriptional activities involved in cellular stress responses. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor that blocks PI3K-mediated signaling pathways involved in cell survival and proliferation, potentially suppressing XAGE1E expression by inhibiting downstream signaling. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG is a heat shock protein 90 (HSP90) inhibitor that disrupts HSP90 chaperone function, leading to the degradation of client proteins involved in cell survival and proliferation, potentially impacting XAGE1E expression. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor that blocks Src-mediated signaling pathways, potentially affecting XAGE1E expression by modulating downstream signaling events involved in cellular proliferation and survival. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a mammalian target of rapamycin (mTOR) inhibitor that suppresses mTOR signaling, leading to inhibition of protein synthesis and cell growth, potentially impacting XAGE1E expression by modulating cellular proliferation. | ||||||
AG-490 | 133550-30-8 | sc-202046C sc-202046A sc-202046B sc-202046 | 5 mg 50 mg 25 mg 10 mg | $82.00 $323.00 $219.00 $85.00 | 35 | |
AG-490 is a Janus kinase (JAK) inhibitor that blocks JAK/STAT signaling, potentially regulating XAGE1E expression by modulating downstream transcriptional activities involved in cell growth and survival. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a mitogen-activated protein kinase kinase (MEK) inhibitor that blocks the MEK/ERK signaling pathway, potentially regulating XAGE1E expression by modulating downstream transcriptional activities. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a vacuolar ATPase inhibitor that prevents lysosomal acidification, leading to impaired autophagy and degradation processes, potentially influencing XAGE1E expression by altering cellular homeostasis. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a sarco/endoplasmic reticulum calcium ATPase (SERCA) inhibitor that disrupts calcium homeostasis and induces endoplasmic reticulum stress, potentially affecting XAGE1E expression through cellular stress responses. | ||||||