WSTF Activators
WSTF Activators encompass a diverse group of compounds that indirectly enhance the activity of WSTF, primarily by modulating chromatin structure and gene expression. 5-Azacytidine and Trichostatin A, by altering DNA methylation and histone acetylation respectively, facilitate WSTF's role in chromatin remodeling and transcriptional regulation. This is particularly important in genes involved in development and DNA damage response. Similarly, Vorinostat (also known as SAHA) and Valproic Acid, through their histone deacetylase inhibiting properties, create a more open chromatin structure that aids WSTF in its regulatory functions. These changes are crucial in facilitating the transcription of genes regulated by WSTF, especially those involved in growth and neuronal development.
In addition, compounds like Sodium Butyrate and MS-275 (Entinostat) further support WSTF's activity by promoting histone acetylation, thereby aiding in chromatin remodeling and the regulation of gene expression related to developmental processes and stress responses. Romidepsin, Panobinostat, and Belinostat, all functioning as histone deacetylase inhibitors, similarly enhance WSTF's role in modifying chromatin structure and regulating transcription, particularly in pathways involved in cell cycle regulation, development, and DNA repair mechanisms. Mocetinostat and Sirtinol, by affecting histone acetylation through different mechanisms, also contribute to the enhancement of WSTF's function in chromatin remodeling and the regulation of gene expression. Collectively, these WSTF Activators, through their targeted effects on chromatin dynamics and gene expression, facilitate the enhancement of WSTF-mediated functions, highlighting the intricate interplay between epigenetic modifications and the regulation of gene expression by WSTF in various cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, indirectly enhances WSTF activity by altering DNA methylation patterns. This alteration in methylation can lead to changes in chromatin structure and gene expression, indirectly enhancing the functional activity of WSTF in chromatin remodeling and regulation of gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, indirectly enhances WSTF activity by affecting histone acetylation. This results in a more open chromatin structure, facilitating WSTF's role in chromatin remodeling and transcriptional regulation, particularly in genes involved in development and DNA damage response. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat, another histone deacetylase inhibitor, enhances WSTF activity similarly to Trichostatin A. By increasing histone acetylation, it promotes chromatin relaxation, which aids WSTF in its function in chromatin remodeling and in regulating the expression of various genes, especially those involved in growth and development. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid, a histone deacetylase inhibitor, indirectly enhances WSTF activity by promoting histone acetylation. This change in chromatin structure supports WSTF's role in chromatin remodeling, facilitating the transcription of genes that WSTF regulates, particularly in neuronal development and DNA repair mechanisms. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, a short-chain fatty acid and histone deacetylase inhibitor, indirectly enhances WSTF activity by promoting histone acetylation. This alteration in chromatin structure aids WSTF's function in chromatin remodeling and transcriptional regulation, especially in genes involved in developmental processes and stress responses. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275, a selective histone deacetylase inhibitor, indirectly enhances WSTF activity. By increasing histone acetylation, it supports WSTF's role in modifying chromatin structure and regulating gene expression, particularly in genes related to development and cellular stress responses. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin, a histone deacetylase inhibitor, enhances WSTF activity by promoting histone acetylation. This leads to a more open chromatin structure, facilitating WSTF's function in chromatin remodeling and in the regulation of gene expression, especially in pathways involved in cell cycle regulation and DNA repair. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat, a potent histone deacetylase inhibitor, indirectly enhances WSTF activity by increasing histone acetylation. This alteration in chromatin structure supports WSTF's role in chromatin remodeling and the regulation of gene expression, particularly in pathways related to cellular growth, development, and response to DNA damage. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
Belinostat, a histone deacetylase inhibitor, indirectly enhances WSTF activity by affecting histone acetylation. This change in chromatin structure aids WSTF in its role in chromatin remodeling and transcriptional regulation, particularly in genes involved in development and stress response mechanisms. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
Mocetinostat, a histone deacetylase inhibitor, enhances WSTF activity by promoting histone acetylation. This change in chromatin structure supports WSTF's function in chromatin remodeling and in regulating gene expression, especially in developmental pathways and DNA damage response. | ||||||