Wnt-3 Inhibitors
Items 1 to 10 of 17 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is known to inhibit glycogen synthase kinase 3 (GSK-3), a negative regulator of the Wnt/β-catenin pathway. By inhibiting GSK-3, lithium chloride can promote the stabilization and accumulation of β-catenin in the cytoplasm, enhancing the Wnt signaling pathway in which Wnt-3 is a key component. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
LGK974 is a small molecule inhibitor that targets the porcupine enzyme, responsible for the palmitoylation of Wnt proteins, including Wnt-Inhibition of porcupine disrupts Wnt-3 secretion and signaling. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $255.00 | ||
PRI-724 is a small molecule that interferes with the interaction between β-catenin and its co-activator CBP, thus inhibiting Wnt-3-mediated transcriptional activation. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
Similar to lithium chloride, by inhibiting GSK-3, this compound can facilitate the accumulation of β-catenin in the cytoplasm, thereby potentiating the Wnt/β-catenin signaling pathway. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $132.00 | 19 | |
IWR-1 is known to inhibit the Wnt response by stabilizing the Axin complex. However, in certain contexts, this stabilization can lead to feedback mechanisms that upregulate components of the Wnt pathway, including Wnt-3. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV939 is a small molecule that promotes the degradation of β-catenin, which is a central component of the Wnt signaling pathway, including Wnt-3 signaling. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid, a histone deacetylase (HDAC) inhibitor, can influence gene expression. By altering chromatin structure and gene expression, valproic acid can indirectly affect the Wnt signaling pathway, potentially activating Wnt-3 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, can modulate gene expression through its nuclear receptors. This activation can influence the Wnt signaling pathway, thereby indirectly activating Wnt-3 activity. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol, through its receptor, can modulate gene expression and cellular processes. This activation can have downstream effects on the Wnt signaling pathway, potentially activating Wnt-3 activity. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
Niclosamide has been investigated for its potential to inhibit Wnt-3 signaling by promoting the degradation of Wnt pathway components. | ||||||