WIPI-1 Inhibitors
WIPI-1 inhibitors, generally speaking, involve chemicals that can interfere with the autophagy process. Wortmannin, LY294002, VPS34-IN1, 3-MA, Spautin-1, SAR405, and Autophinib all target the production of PI(3)P, an essential phosphoinositide for autophagosome formation, by inhibiting either PI3K in general or specifically VPS34, a class III PI3K. By inhibiting the production of PI(3)P, these chemicals can indirectly affect the function of WIPI-1, which binds to PI(3)P to initiate autophagosome formation.
Alternatively, Bafilomycin A1, Chloroquine, and Hydroxychloroquine inhibit the fusion between autophagosomes and lysosomes, an essential step in the autophagy process. This inhibition can indirectly influence the function of WIPI-1, which is involved in autophagosome formation. Lastly, E64d and Pepstatin A inhibit the lysosomal degradation of autophagosomes by inhibiting cysteine and aspartyl proteases, respectively. By inhibiting the final step of the autophagy process, these chemicals can indirectly affect the function of WIPI-1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a covalent inhibitor of PI3K, the enzyme that produces PI(3)P. By inhibiting PI3K, it can indirectly influence WIPI-1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a reversible inhibitor of PI3K. By inhibiting PI3K, it can indirectly influence WIPI-1. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-MA inhibits VPS34, the class III PI3K that produces PI(3)P, indirectly influencing WIPI-1. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Spautin-1 promotes the degradation of VPS34 complexes, indirectly affecting WIPI-1. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine inhibits autophagosome-lysosome fusion, indirectly influencing WIPI-1. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
E64d is a cysteine protease inhibitor that inhibits the lysosomal degradation of autophagosomes, indirectly affecting WIPI-1. | ||||||
SAR405 | 1523406-39-4 | sc-507416 | 1 mg | $125.00 | ||
SAR405 is a specific and potent VPS34 inhibitor, indirectly affecting WIPI-1. | ||||||