WIF-1 Inhibitors
WIF-1 inhibitors represent a class of chemicals that modulate the activity of the Wnt Inhibitory Factor-1 (WIF-1), a crucial player in the regulation of Wnt signaling. WIF-1 functions as a secreted antagonist of Wnt ligands, sequestering them from the Wnt receptor complex and preventing the initiation of Wnt signaling cascades. The inhibitors listed above act either directly on WIF-1 or indirectly through modulation of key components in the Wnt signaling pathway. LGK-974, for instance, operates by inhibiting Porcupine, an enzyme essential for the secretion of Wnt ligands. This inhibition results in decreased Wnt ligand availability, indirectly influencing WIF-1 by enhancing its antagonistic effect on the remaining Wnt ligands. Similarly, ICG-001 targets CREB-binding protein (CBP), disrupting Wnt target gene transcription and indirectly impacting WIF-1 by altering the transcriptional regulation of Wnt signaling.
Several inhibitors, such as XAV939, IWR-1, and BC2059, target tankyrase, stabilizing Axin, a key component of the β-catenin destruction complex. This stabilization promotes β-catenin degradation, indirectly influencing WIF-1 by enhancing its antagonistic effect on Wnt ligands. Other compounds like PRI-724 and its analogs directly inhibit the interaction between β-catenin and CBP, disrupting WIF-1 regulation by altering transcriptional events downstream of Wnt signaling. The modulation of Wnt signaling by these inhibitors provides valuable insights into conditions where dysregulation of Wnt signaling, and consequently WIF-1 activity, plays a crucial role. Understanding the diverse mechanisms by which these inhibitors operate opens avenues for targeted interventions in diseases associated with aberrant Wnt signaling.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $359.00 $1295.00 | 2 | |
LGK-974 is a small molecule inhibitor that selectively targets the Wnt pathway by inhibiting Porcupine, an acyltransferase essential for Wnt ligand secretion. By blocking Wnt secretion, LGK-974 indirectly affects WIF-1 by preventing its antagonism of Wnt ligands, thus leading to downregulation of Wnt signaling and modulation of cellular processes regulated by WIF-1-mediated pathways. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV939 is a tankyrase inhibitor that indirectly affects WIF-1 by stabilizing Axin, a key component of the β-catenin destruction complex. WIF-1 antagonizes Wnt signaling by binding to Wnt ligands, and the stability of Axin is crucial for proper β-catenin degradation. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $260.00 | ||
PRI-724 is a small molecule inhibitor that selectively targets the interaction between β-catenin and its co-activator CBP. As WIF-1 inhibits Wnt signaling by interacting with Wnt ligands and sequestering them from the receptor complex, PRI-724 indirectly modulates WIF-1 by disrupting the interaction between β-catenin and CBP. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1 is a tankyrase inhibitor that indirectly influences WIF-1 by stabilizing Axin, a component of the β-catenin destruction complex. WIF-1 antagonizes Wnt signaling by binding to Wnt ligands, and the stability of Axin is crucial for proper β-catenin degradation. | ||||||
KY02111 | 1118807-13-8 | sc-397043 sc-397043A | 5 mg 25 mg | $79.00 $336.00 | ||
KY02111 is a small molecule inhibitor of Wnt/β-catenin signaling that indirectly influences WIF-1 by modulating the activity of the destruction complex. WIF-1 inhibits Wnt signaling by binding to Wnt ligands, and the destruction complex regulates the degradation of β-catenin. | ||||||
NSC 668036 | 144678-63-7 | sc-507412 | 5 mg | $175.00 | ||
NSC668036 is a small molecule inhibitor that targets the Wnt/β-catenin pathway by disrupting the interaction between β-catenin and its co-activator CBP. Given that WIF-1 inhibits Wnt signaling by interacting with Wnt ligands, NSC668036 indirectly influences WIF-1 by disrupting the interaction between β-catenin and CBP. | ||||||
Cercosporin | 35082-49-6 | sc-255013 | 5 mg | $459.00 | 1 | |
Cercosporin is a tankyrase inhibitor that indirectly influences WIF-1 by stabilizing Axin, a component of the β-catenin destruction complex. WIF-1 inhibits Wnt signaling by binding to Wnt ligands, and the stability of Axin is crucial for proper β-catenin degradation. | ||||||
WAY 262611 | sc-397019 sc-397019A | 5 mg 25 mg | $131.00 $520.00 | 2 | ||
WAY-262611 is a small molecule inhibitor of the Wnt pathway that indirectly influences WIF-1 by modulating the activity of the destruction complex. WIF-1 inhibits Wnt signaling by binding to Wnt ligands, and the destruction complex regulates the degradation of β-catenin. | ||||||