WAY 262611
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WAY 262611 is a selective and potent antagonist of the 5-HT6 receptor. It functions by binding to the 5-HT6 receptor and inhibiting its activation by serotonin. This interaction prevents the downstream signaling that would normally occur upon receptor activation. By blocking the 5-HT6 receptor, WAY 262611 modulates the release of various neurotransmitters, including dopamine and acetylcholine, in the brain. This modulation of neurotransmitter release is thought to be involved in cognitive processes and memory formation. The antagonist activity of WAY 262611 at the 5-HT6 receptor has been studied for its potential effects on mood and behavior. WAY 262611′s mechanism of action involves targeting the 5-HT6 receptor and modulating neurotransmitter release in the brain, potentially impacting cognitive function and behavior.
WAY 262611 References
- GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition. | Enochson, L., et al. 2014. Osteoarthritis Cartilage. 22: 566-77. PMID: 24561281
- Curcumin raises lipid content by Wnt pathway in hepatic stellate cell. | Zhang, F., et al. 2016. J Surg Res. 200: 460-6. PMID: 26414021
- Activation of dickkopf-1 and focal adhesion kinase pathway by tumour necrosis factor α induces enhanced migration of fibroblast-like synoviocytes in rheumatoid arthritis. | Choe, JY., et al. 2016. Rheumatology (Oxford). 55: 928-38. PMID: 26715774
- Antimetastasis Effect of Astragalus membranaceus-Curcuma zedoaria via β-Catenin Mediated CXCR4 and EMT Signaling Pathway in HCT116. | Tan, X., et al. 2019. Evid Based Complement Alternat Med. 2019: 9692350. PMID: 31275425
- Tanshinone IIA promotes cardiac differentiation and improves cell motility by modulating the Wnt/β‑catenin signaling pathway. | Li, K., et al. 2020. Mol Med Rep. 22: 1839-1846. PMID: 32582982
- Tanshinone II A improves the chemosensitivity of breast cancer cells to doxorubicin by inhibiting β-catenin nuclear translocation. | Li, S., et al. 2021. J Biochem Mol Toxicol. 35: e22620. PMID: 32886829
- MicroRNA-320a-containing exosomes from human umbilical cord mesenchymal stem cells curtail proliferation and metastasis in lung cancer by binding to SOX4. | Xie, H. and Wang, J. 2022. J Recept Signal Transduct Res. 42: 268-278. PMID: 34096448
- Dickkopf-1 Inhibition Reactivates Wnt/β-Catenin Signaling in Rhabdomyosarcoma, Induces Myogenic Markers In Vitro and Impairs Tumor Cell Survival In Vivo. | Giralt, I., et al. 2021. Int J Mol Sci. 22: PMID: 34884726
- Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer's disease. | Tong, XK., et al. 2022. Cell Death Dis. 13: 325. PMID: 35397630
- DOC2B is a negative regulator of Wnt/β-catenin signaling pathway in cervical cancer. | Adiga, D., et al. 2022. Pharmacol Res. 180: 106239. PMID: 35500882
- Pharmacological inhibition of DKK1 promotes spine fusion in an ovariectomized rat model. | Li, Z., et al. 2022. Bone. 162: 116456. PMID: 35688363
- Combination therapy of DKK1 inhibition and NKG2D chimeric antigen receptor T cells for the treatment of gastric cancer. | Zhang, Y., et al. 2023. Cancer Sci.. PMID: 37151176
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WAY 262611, 5 mg | sc-397019 | 5 mg | $131.00 | |||
WAY 262611, 25 mg | sc-397019A | 25 mg | $520.00 |