WDR87, a member of the WD repeat protein family, is characterized by its role in cellular processes through protein-protein interactions. WD repeat proteins are known for their structural motif that facilitates complex formation with multiple proteins, impacting various signaling pathways and cellular functions such as cell cycle control, gene expression, and intracellular trafficking. WDR87, although not as extensively studied as other proteins in its family, is believed to participate in similar regulatory activities within the cell. These activities might include roles in the organization of protein complexes that are crucial for the proper functioning of cellular machinery, possibly affecting both the nucleus and cytoplasmic components. Understanding the specific biological pathways influenced by WDR87 is essential for determining its role in health and disease.
Inhibiting WDR87 could theoretically provide insights into its function and potential implications for cellular regulation and disease pathogenesis. The inhibition of WDR87 might be achieved through several strategies, focusing on disrupting its interaction with other proteins or interfering with its structural integrity. One potential method of inhibition could involve the use of small molecule inhibitors that specifically target the WD repeat domains, preventing the protein from forming necessary complexes with its partners. This could elucidate the pathways and processes dependent on its regulatory functions. Another approach might include RNA interference techniques, such as siRNA, which could be used to decrease the expression levels of WDR87, thereby reducing its availability for participation in critical cellular functions. By inhibiting WDR87, researchers could potentially uncover novel aspects of cell regulation mechanisms, offering insights into the role of WD repeat proteins in cellular homeostasis and the etiology of diseases where protein-protein interactions are disrupted. These insights could further aid in the development of targeted therapies for diseases associated with protein misregulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that targets the MAPK/ERK pathway. Through inhibiting MEK, it suppresses the phosphorylation of ERK, impacting downstream targets like WDR87. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor that disrupts the PI3K/Akt/mTOR pathway. It prevents the phosphorylation of Akt, thereby reducing the activity of any downstream proteins like WDR87. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor that blocks the p38 alpha and beta isoforms, altering the phosphorylation of substrates in the MAPK pathway and thus impacting WDR87 indirectly. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, which in turn downregulates the PI3K/Akt/mTOR pathway. This can suppress mTOR activity and affect proteins regulated by this pathway, such as WDR87. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that affects the JNK signaling pathway. It inhibits the phosphorylation of c-Jun, affecting the AP-1 transcription factor and thereby impacting WDR87. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor that influences the Rho/ROCK pathway. By inhibiting ROCK, it affects cytoskeletal dynamics, potentially impacting proteins such as WDR87. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
Src family kinase inhibitor that prevents Src-mediated phosphorylation. This inhibition can modulate proteins downstream in the Src signaling pathway like WDR87. | ||||||
ZM 336372 | 208260-29-1 | sc-202857 | 1 mg | $46.00 | 2 | |
Raf-1 kinase inhibitor that can downregulate MAPK/ERK signaling. It inhibits Raf-1 phosphorylation, which can in turn influence downstream targets like WDR87. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
CaMKII inhibitor that blocks calcium/calmodulin-dependent pathways. It inhibits CaMKII phosphorylation, affecting downstream proteins that might include WDR87. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
JAK2 inhibitor that targets the JAK/STAT pathway. By blocking JAK2, it impacts STAT3 activation, affecting downstream proteins possibly involving WDR87. | ||||||