WDR86 Inhibitors
WDR86 inhibitors belong to a class of chemical compounds specifically designed to target and modulate the activity of the WDR86 protein. The WDR86 protein, also known as WD repeat-containing protein 86, is a member of the WD repeat family of proteins that play crucial roles in various cellular processes. WD repeat proteins are characterized by the presence of a repeated structural motif, the WD repeat, which consists of approximately 40 amino acids forming a β-propeller structure. WDR86, in particular, has been implicated in cellular functions related to signal transduction, gene expression, and protein-protein interactions.
Chemical compounds classified as WDR86 inhibitors are designed to selectively bind to the WDR86 protein, thereby influencing its function and disrupting the cellular pathways in which it is involved. The precise mechanisms through which WDR86 inhibitors exert their effects may involve blocking specific binding sites, altering the conformation of the protein, or interfering with its interactions with other cellular components. These inhibitors are developed with the aim of providing researchers with valuable tools to investigate the biological roles of WDR86 and to explore avenues that may arise from a deeper understanding of its molecular functions. The development of WDR86 inhibitors represents a targeted approach in chemical biology to unravel the intricacies of cellular processes associated with WD repeat proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent phosphoinositide 3-kinase (PI3K) inhibitor. WDR86 inhibition may be achieved indirectly as PI3K signaling is crucial for many cellular processes, including those related to the functions of WD repeat-containing proteins. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor that can impede the PI3K/Akt pathway. Since WDR86 may be functionally linked to pathways regulated by PI3K, its activity could be indirectly reduced by LY294002. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a kinase downstream of PI3K/Akt signaling. By inhibiting mTOR, rapamycin could indirectly affect WDR86 activity if WDR86 is involved in mTOR-regulated pathways. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that can influence various signaling pathways, potentially including those associated with WDR86, leading to its indirect inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, which is part of the MAPK/ERK pathway. By inhibiting MEK, U0126 may indirectly decrease WDR86 activity if WDR86 is involved in ERK-mediated signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38 MAPK, it could reduce the functional activity of WDR86 if WDR86 operates within the p38 MAPK pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, part of the MAPK pathway. Inhibition of JNK could result in decreased WDR86 activity if WDR86 is implicated in JNK signaling. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor; by disrupting protein degradation pathways, it could indirectly lead to altered regulation of WDR86 if it is subject to proteasomal regulation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is another proteasome inhibitor that could affect WDR86 indirectly by altering the degradation of proteins that interact with or regulate WDR86 activity. | ||||||
Cyclosporine | 79217-60-0 | sc-358111 sc-358111A | 100 mg 1 g | $191.00 $992.00 | 2 | |
Cyclosporine inhibits calcineurin, by disrupting calcineurin signaling, it could potentially reduce WDR86 activity if WDR86 is linked to the calcineurin pathway. | ||||||