WDR86 Activators
WDR86 Activators encompass a diverse array of chemical compounds that indirectly promote the functional activity of WDR86 through various signaling cascades. Forskolin and dibutyryl cAMP (db-cAMP), both known to elevate intracellular cAMP levels, indirectly enhance WDR86's activity by activating protein kinase A (PKA), which then may phosphorylate proteins within signaling networks where WDR86 operates. Similarly, 8-Bromo-cAMP, by acting as a cAMP analog, activates PKA and can modulate WDR86's associated pathways through phosphorylation events. Isoquinolinesulfonamide (H-89), as an inhibitor of PKA, can alter the balance of signaling pathways, possibly leading to an indirect enhancement of WDR86's functional role by reducing competitive phosphorylation events. Moreover, the activation of protein kinase C (PKC) by Phorbol 12-myristate 13-acetate (PMA) could result in the phosphorylation of proteins that are part of WDR86's signaling pathways, thereby influencing its activity. Epigallocatechin gallate (EGCG), through its inhibition of various kinases, has the potential to modulate phosphorylation states within WDR86's signaling networks, indirectly enhancing its functional role.
Additionally, the modulation of intracellular calcium levels plays a significant role in the indirect activation of WDR86. Ionomycin and A23187, both calcium ionophores, increase calcium levels within the cell, thereby activating calcium-dependent signaling pathways that could influence WDR86 activity. Thapsigargin, by inhibiting SERCA, also raises cytosolic calcium levels, potentially enhancing WDR86's function by affecting its associated calcium-signaling proteins and pathways. The intricate interplay between these activators and cellular signaling mechanisms suggests that WDR86's activity could be indirectly augmented through the modulation of kinase activities, cAMP levels, and calcium signaling. Collectively, these WDR86 Activators, while diverse in their mechanisms of action, converge on common pathways to facilitate the enhancement of WDR86-mediated cellular processes without the need for direct activation or increased expression of the protein itself.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a diterpene that activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can activate PKA, which may indirectly enhance the activity of WDR86 by phosphorylation of proteins within its associated signaling networks, thereby potentially influencing its role in cellular processes. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. By mimicking cAMP and activating PKA, it may indirectly enhance the activity of WDR86 through phosphorylation cascades that WDR86 is associated with, affecting its function in cellular signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. This rise in calcium can activate calmodulin-dependent kinase (CaMK), which may indirectly enhance the functional activity of WDR86 by modulating proteins in calcium signaling pathways that WDR86 is part of, thereupon influencing its cellular role. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a PKC activator that mimics diacylglycerol (DAG). Activation of PKC can lead to phosphorylation of proteins within signaling pathways that WDR86 is a part of, thus indirectly enhancing the functional activity of WDR86 by modulation of these pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is another cAMP analog that activates PKA. Similar to 8-Bromo-cAMP, db-cAMP may indirectly enhance the functional activity of WDR86 by activating PKA and influencing the phosphorylation state of proteins within WDR86's signaling pathways, thereby modulating its cellular functions. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium levels. The resultant activation of calcium-dependent signaling pathways may indirectly enhance the activity of WDR86 by influencing the proteins and pathways that interact with or regulate WDR86's function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels, similar to Ionomycin. This elevation of calcium can activate calcium-dependent proteins and pathways that may indirectly enhance the functional activity of WDR86 by modulating associated signaling networks. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that has been shown to inhibit several protein kinases. By modulating kinase activity, EGCG may indirectly enhance the functional activity of WDR86 by altering the phosphorylation state of proteins within WDR86's associated pathways | ||||||