WDR72 Inhibitors
WDR72 inhibitors comprises a group of compounds designed to target and modulate the activity of the WDR72 protein. WDR72, short for WD repeat-containing protein 72, is a member of the WD repeat protein family, characterized by the presence of a conserved WD repeat domain. This class of inhibitors specifically interacts with the WDR72 protein, which is involved in various cellular processes, including signal transduction, cell cycle regulation, and protein-protein interactions. The WD repeat domain in WDR72 is crucial for mediating protein-protein interactions, and inhibitors of this class are designed to disrupt these interactions by binding to specific regions of the protein, thereby modulating its function.
Structurally, WDR72 inhibitors exhibit a diverse range of chemical scaffolds, reflecting the intricate nature of protein-ligand interactions. Researchers have employed computational and structural biology techniques to identify key binding sites on the WDR72 protein, facilitating the rational design of inhibitors with high affinity and selectivity. Understanding the structural nuances of WDR72 inhibitors is essential for optimizing their pharmacokinetic properties and enhancing their effectiveness in modulating WDR72 activity. Ongoing research in this field aims to elucidate the precise mechanisms through which WDR72 inhibitors exert their effects, contributing to the broader understanding of WD repeat proteins and opening avenues for potential applications in various cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. It indirectly affects WDR72 by inhibiting protein kinase C (PKC), which is possibly involved in phosphorylation events that could be crucial for WDR72's functional regulation. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of the vacuolar-type H+-ATPase. By inhibiting this pump, it affects the acidification of organelles, potentially disrupting the environment that WDR72 may require for its function in vesicular transport or biomineralization. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK). It may influence WDR72 by altering cytoskeletal dynamics and trafficking pathways where WDR72 might be involved, leading to indirect inhibition of its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK). It indirectly affects WDR72 by inhibiting the MAPK/ERK pathway, potentially modulating phosphorylation states of proteins associated with WDR72 function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) pump inhibitor. It influences calcium homeostasis, which could affect biomineralization processes involving WDR72. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A disrupts microfilament organization by binding to actin monomers. It may indirectly inhibit WDR72 by impairing cytoskeletal-dependent trafficking processes. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent. By disturbing microtubule dynamics, it could impede trafficking routes and processes where WDR72 is hypothesized to play a role. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. It could influence WDR72 function by modulating vesicular trafficking and autophagy processes that WDR72 may be part of. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor with a similar potential to LY294002 to affect vesicular trafficking and autophagy, thereby indirectly influencing WDR72 function. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporine A is an immunosuppressant that inhibits calcineurin. By altering calcium signaling, it might indirectly affect the role of WDR72 in biomineralization. | ||||||