WDR65 Inhibitors
WDR65 inhibitors encompass a range of chemical compounds that constrain the functional activity of WDR65 through their influence on various signaling pathways and cellular processes. Staurosporine, a broad-spectrum kinase inhibitor, non-specifically disrupts kinase-mediated signaling, which could diminish the functional requisites of WDR65 in these pathways. Similarly, the PI3K inhibitors LY 294002 and Wortmannin, along with the dual PI3K/mTOR inhibitor GSK2126458, may reduce WDR65 activity by diminishing PI3K/AKT signaling, a pathway that may be critical for WDR65's role in the cell. The specific MEK inhibitors PD 98059, U0126, and Cobimetinib, which abate ERK activation in the MAPK pathway, could also lead to reduced activity of WDR65 if it is implicated in ERK-mediated processes. Triciribine, targeting AKT, and Rapamycin, an mTOR inhibitor, further contribute to the potential downregulation of WDR65 function through their respective inhibitory actions.
In addition to the above, Bortezomib's proteasome inhibition could lead to a general disturbance in cellular homeostasis, indirectly affecting the functional capacity of WDR65. The JNK pathway, targeted by SP600125, and p38 MAPK, targeted by SB 203580, are both associated with cellular stress responses; their inhibition could reduce WDR65 activity if it is involved in these stress-related signaling pathways. Inhibitors such as these, by curtailing the activity of signaling molecules and pathways that WDR65 may be functionally integrated with, offer a multifaceted approach to indirectly inhibit the protein's activity through the disruption of its potential signaling intermediates and modulators.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent non-selective inhibitor of protein kinases that can indirectly inhibit WDR65 by disrupting various kinase-mediated signaling pathways that WDR65 might be involved in, leading to diminished cellular processes where WDR65 is functionally necessary. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of PI3K, which in turn can reduce AKT signaling; since WDR65 has been implicated in cellular processes that could be modulated by PI3K/AKT, its functional activity may be indirectly reduced when this pathway is inhibited. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of MEK, which acts upstream of ERK in the MAPK pathway; WDR65, if involved in processes regulated by this pathway, would experience reduced functional activity due to the dampening of MAPK signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can diminish cellular growth and proliferation signals; if WDR65 is involved in these processes, its activity could be indirectly suppressed by the inhibition of mTOR signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A selective inhibitor of p38 MAPK, leading to reduced inflammatory responses and stress signaling; WDR65's function could be indirectly diminished if it plays a role in pathways that are sensitive to p38 MAPK activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that can lead to an accumulation of misfolded proteins, indirectly affecting cellular pathways including those where WDR65 may have a role, thereby potentially diminishing its functional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A potent inhibitor of PI3K, similarly diminishing AKT signaling and potentially reducing WDR65 function if it is involved in PI3K/AKT-regulated processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which is involved in apoptotic and stress signaling pathways; inhibition of JNK could indirectly reduce WDR65's activity if it is implicated in JNK-related pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
An inhibitor of MEK1/2, similar to PD98059, which would indirectly inhibit ERK activation and potentially decrease the functional activity of WDR65 if it is involved in ERK-mediated processes. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
An AKT inhibitor that could indirectly inhibit WDR65 by diminishing the downstream effects of PI3K/AKT signaling pathways in which WDR65 could possibly be involved. | ||||||