WDR33 Inhibitors
The term WDR33 Inhibitors refers to a class of chemical compounds designed to specifically target and inhibit the activity of the WDR33 protein. WDR33, or WD repeat-containing protein 33, is a protein encoded by the WDR33 gene in humans. It plays a crucial role in various cellular processes, particularly in the regulation of transcription and mRNA splicing. The protein contains multiple WD40 repeats, which are structural motifs involved in protein-protein interactions. WDR33 is known to be associated with spliceosome assembly, a complex molecular machinery responsible for the removal of introns from pre-mRNA, thus facilitating the formation of mature mRNA. Inhibition of WDR33 activity by specific small molecules aims to modulate these critical cellular functions, offering a means to influence gene expression and splicing processes.
Structurally, WDR33 Inhibitors are designed to interact with the active site or binding pocket of the WDR33 protein, preventing its normal functioning. These inhibitors can be small organic molecules with a specific chemical arrangement that enables them to bind selectively to WDR33. The development of WDR33 inhibitors involves a detailed understanding of the protein's structure and the identification of key binding sites. Researchers employ various computational and experimental techniques, such as structure-based drug design and high-throughput screening, to identify and optimize inhibitors. The goal is to create molecules that can effectively disrupt the interactions between WDR33 and its molecular partners, ultimately modulating cellular processes dependent on the proper functioning of WDR33.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is a diterpene triepoxide that can inhibit general transcription by targeting transcription factors and components of the RNA polymerase II (Pol II) complex, potentially affecting WDR33's role in mRNA processing. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin is a cyclic peptide toxin from the Amanita phalloides mushroom, which inhibits RNA Pol II. By inhibiting Pol II, α-Amanitin may indirectly affect WDR33's function in mRNA processing. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB is a kinase inhibitor that targets the positive transcription elongation factor b (P-TEFb), which is required for Pol II's transition into elongation; hence, it may indirectly affect WDR33's function. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol inhibits CDK9, a component of P-TEFb, potentially disrupting transcription elongation and indirectly impacting WDR33's role in pre-mRNA processing. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 is a BET bromodomain inhibitor that disrupts the recognition of acetylated histones, potentially altering transcription and indirectly affecting WDR33's function. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Pladienolide B is an inhibitor of the spliceosome, specifically targeting the SF3B complex, which might influence WDR33's role in mRNA maturation indirectly. | ||||||
Tanshinone IIA | 568-72-9 | sc-200932 sc-200932A | 5 mg 25 mg | $88.00 $316.00 | 22 | |
Tanshinone IIA is a diterpene quinone found in Salvia miltiorrhiza that can interfere with various signaling pathways and may indirectly impact WDR33's associated pathways. | ||||||
Oxamflatin | 151720-43-3 | sc-205960 sc-205960A | 1 mg 5 mg | $151.00 $470.00 | 4 | |
Oxamflatin is a histone deacetylase inhibitor that modulates chromatin structure, possibly affecting transcription and indirectly WDR33's function. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275 is a selective histone deacetylase inhibitor that can alter gene expression and potentially impact WDR33's role in mRNA processing indirectly. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a competitive inhibitor of p300/CBP histone acetyltransferase, potentially affecting transcription and indirectly WDR33's function. | ||||||