WDPCP Inhibitors
WDPCP (WD repeat-containing and planar cell polarity effector) inhibitors belong to a distinctive chemical class characterized by their ability to modulate the function of the WDPCP protein. WDPCP is a crucial component of the non-canonical Wnt/planar cell polarity (PCP) signaling pathway, a conserved pathway essential for the establishment of tissue polarity during development. The WDPCP protein, harboring multiple WD40 repeats, plays a pivotal role in coordinating cellular processes such as cell migration, tissue organization, and morphogenesis. Inhibitors targeting WDPCP exert their effects by disrupting the normal functioning of this protein, thereby influencing the downstream signaling events associated with the PCP pathway.
The mechanism of action of WDPCP inhibitors involves interference with the protein-protein interactions mediated by WDPCP's WD40 repeats. By binding to specific regions of WDPCP, these inhibitors impede its ability to participate in the formation of multiprotein complexes essential for transmitting PCP signals within cells. This disruption alters the precise coordination of cellular activities regulated by the PCP pathway, leading to morphological changes and alterations in tissue organization. The development and study of WDPCP inhibitors contribute significantly to our understanding of the intricacies of the Wnt/PCP signaling cascade, offering valuable insights into the molecular mechanisms governing tissue polarity and cellular movements during embryonic development and providing a platform for further research into related biological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β, an enzyme that can regulate processes intertwined with planar cell polarity (PCP) pathways, where WDPCP is involved. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
A selective GSK-3β inhibitor that can alter Wnt signaling, potentially affecting the PCP pathway and the role of WDPCP. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
An inhibitor of Wnt production, which could indirectly affect the signaling processes regulated by WDPCP. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Targets β-catenin degradation, thereby influencing Wnt/β-catenin signaling connected to PCP and potentially WDPCP. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
A PORCN inhibitor which inhibits Wnt ligand palmitoylation and secretion, potentially influencing WDPCP function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An ERK pathway inhibitor, could alter downstream signals affecting processes where WDPCP is implicated. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which might intersect with non-canonical Wnt signaling and thus indirectly influence WDPCP. | ||||||
Casein Kinase I Inhibitor, D4476 | 301836-43-1 | sc-202522 | 1 mg | $97.00 | 6 | |
An inhibitor of casein kinase 1, a kinase that can be involved in Wnt signaling and indirectly affect WDPCP's role in PCP. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
GSK-3β inhibitor that can modulate Wnt signaling, potentially altering the biological context in which WDPCP operates. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
An eIF2α phosphatase inhibitor, may impact protein synthesis downstream of signals affected by WDPCP. | ||||||