WDPCP Antibody (A-5): sc-514151

WDPCP Antibody (A-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects WDPCP of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-WDPCP antibody (A-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. WDPCP, also known as C2orf86, fritz, hFrtz, or DKFZp686C12204, is a 746 amino acid protein characterized by the presence of two WD repeats and exists in three alternatively spliced isoforms. WDPCP plays a crucial role in regulating cilia formation and function, which is essential for various cellular processes, including signaling pathways and cellular motility. Proper cilia function is vital for maintaining tissue homeostasis and organ development, and defects in cilia can lead to diseases known as ciliopathies, which can affect multiple organ systems. WDPCP is encoded by a gene located on human chromosome 2p15, a chromosome comprising approximately 8% of the human genome and associated with various genetic disorders. Understanding WDPCP function and implications in cilia-related diseases highlights its importance in both basic biology and potential therapeutic approaches.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

WDPCP Antibody (A-5) References:

1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4.  |  Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
2. Evidence for an ancestral alphoid domain on the long arm of human chromosome 2.  |  Avarello, R., et al. 1992. Hum Genet. 89: 247-9. PMID: 1587535
3. ABCA12 is the major harlequin ichthyosis gene.  |  Thomas, AC., et al. 2006. J Invest Dermatol. 126: 2408-13. PMID: 16902423
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6. Spectrum of ALMS1 variants and evaluation of genotype-phenotype correlations in Alström syndrome.  |  Marshall, JD., et al. 2007. Hum Mutat. 28: 1114-23. PMID: 17594715
7. Compound heterozygous ABCA12 mutations including a novel nonsense mutation underlie harlequin ichthyosis.  |  Akiyama, M., et al. 2007. Dermatology. 215: 155-9. PMID: 17684380
8. Alström syndrome.  |  Marshall, JD., et al. 2007. Eur J Hum Genet. 15: 1193-202. PMID: 17940554
9. Origin of human chromosome 2: an ancestral telomere-telomere fusion.  |  IJdo, JW., et al. 1991. Proc Natl Acad Sci U S A. 88: 9051-5. PMID: 1924367

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WDPCP Antibody (A-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-WDPCP Antibody (A-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WDPCP Antibody (A-5) Specifications

Alternate Product Name: WDPCP

Product Clone Name: A-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 533-559

Epitope Target: WDPCP

Epitope Species: human

Product Reactivity/Detection: WDPCP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for WDPCP Antibody (A-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin