WAPL Inhibitors
These chemicals are not direct inhibitors of WAPL but could influence WAPL function by affecting the proteins and pathways that regulate cohesin. ATR and Aurora B inhibitors, for example, can disrupt cell cycle checkpoints and chromosome segregation. Similarly, inhibitors of enzymes like PLK1, CDK1, and the proteasome could indirectly impact the release of cohesin from chromosomes, a process with which WAPL is closely associated.
In the absence of direct WAPL inhibitors, the focus on chemicals like these provides an indirect approach to understanding and influencing WAPL's role in cell division. By affecting the activity of kinases that phosphorylate components of the cohesin complex or by altering the stability of cohesin on chromosomes through proteasome inhibition, one can potentially modulate the function of WAPL.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
Inhibits ATR kinase that regulates the cell cycle checkpoints and cohesion, potentially affecting WAPL's role in cohesin release. | ||||||
Hesperadin | 422513-13-1 | sc-490384 | 10 mg | $304.00 | ||
Inhibits Aurora B kinase, part of the chromosomal passenger complex, which could affect WAPL's regulation of cohesin removal during mitosis. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
Inhibits Polo-like kinase 1, which is involved in mitotic entry and cohesin regulation, potentially influencing WAPL function. | ||||||
RO-3306 | 872573-93-8 | sc-358700 sc-358700A sc-358700B | 1 mg 5 mg 25 mg | $66.00 $163.00 $326.00 | 37 | |
Inhibits Cyclin-dependent kinase 1, key for mitosis progression; could indirectly influence the function of WAPL in cohesin regulation. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
Inhibits tankyrase, affecting Wnt signaling and potentially influencing WAPL-mediated cohesin release indirectly. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Inhibits the bromodomain and extraterminal (BET) family of proteins; could indirectly impact WAPL function via chromatin remodeling. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Inhibits histone deacetylases, affecting chromatin structure and potentially WAPL's interaction with cohesin on chromatin. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Inhibits proteasome activity, which could stabilize cohesin on chromatin and indirectly affect WAPL activity. | ||||||
BTO-1 | 40647-02-7 | sc-204206 | 2 mg | $120.00 | 3 | |
Targets Shugoshin 1, a protector of cohesin; could indirectly modulate WAPL's role in cohesin protection and release. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
Inhibits Wnt production, potentially affecting cell cycle regulation and indirectly WAPL's activity. | ||||||