VWC2L Inhibitors
VWC2L Inhibitors are characterized by their capacity to interfere with a wide array of signaling pathways and cellular processes that VWC2L is suspected to participate in. For example, inhibitors targeting kinases such as LY294002 and PD98059 affect the phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways respectively. These pathways play a critical role in cellular proliferation, migration, and other cellular activities. Other inhibitors like Y-27632 and SB431542 are more specialized, focusing on Rho-associated kinase (ROCK) and transforming growth factor-beta (TGF-β) receptor respectively, thereby affecting cellular adhesion and the extracellular matrix, where VWC2L might be functional.
Moreover, the chemical class is also enriched by inhibitors affecting smaller GTPases and structural proteins, such as NSC23766, which targets Rac1, or Wiskostatin and Blebbistatin, which act on N-WASP and myosin II respectively. The inclusion of such inhibitors reflects the need for a comprehensive approach to modulate the diverse cellular roles that VWC2L can perform, from actin polymerization to Ras signaling. Each of these chemicals serves to inhibit specific functions, whether it's cellular motility, adhesion, or signal transduction, thereby providing a multi-faceted approach to inhibiting VWC2L.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K, a crucial kinase in multiple cellular processes. Impedes downstream processes where VWC2L is involved. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Blocks MEK, a part of the MAPK pathway. Inhibits cell signaling cascades that can involve VWC2L. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor, affecting actin cytoskeleton rearrangement. As VWC2L can play a role in cellular adhesion, this compound interferes with that process. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Inhibits TGF-β receptor, which modulates extracellular matrix. Disrupts the activity where VWC2L may be a player. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
Inhibits Src family kinases. Affects pathways like cellular adhesion and migration that can involve VWC2L. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
Rac1 inhibitor that disrupts small GTPase activities. This impacts cellular processes like motility that may involve VWC2L. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor affecting cell cycle and proliferation. Can disrupt signaling pathways involving VWC2L. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Inhibits N-WASP activation, affecting actin polymerization. As VWC2L can be related to adhesion, this interrupts that potential function. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Myosin II inhibitor that can affect cell motility and adhesion. Alters the cellular processes that VWC2L may be involved in. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Microtubule destabilizing agent affecting cell structure. Impacts functions where VWC2L can play a role. | ||||||