VSTM4 Inhibitors
Chemical inhibitors of VSTM4 can affect immune regulation through various molecular pathways by interacting with different aspects of cell signaling and immune cell function. Palmitoleic acid incorporates into cell membranes, which may change membrane fluidity and, consequently, receptor signaling, including the signaling activities of VSTM4. Glycyrrhizin targets HMGB1, a component of the inflammatory response, thus inhibiting pathways in which VSTM4 is involved. Similarly, both parthenolide and andrographolide exert their effects by blocking NF-κB activation, a critical factor in immune response regulation, which in turn affects the signal transduction of VSTM4. Epigallocatechin gallate, by inhibiting T-cell activation and cytokine production, can interfere with the immune response processes associated with VSTM4.
Continuing with this theme, curcumin suppresses NF-κB activation and pro-inflammatory cytokine production, which can influence VSTM4's modulatory functions within the immune system. Resveratrol modulates sirtuin activity, which has downstream effects on NF-κB signaling pathways, thus affecting VSTM4 functions. Quercetin inhibits phosphatidylinositol 3-kinase, a key player in cell survival signaling, indirectly impacting VSTM4's regulatory roles. Genistein targets tyrosine kinases involved in various signaling pathways, including those relevant to VSTM4's role in immune responses. Apigenin affects VSTM4 by modulating signaling pathways mediated by NF-κB. Baicalin acts by inhibiting T-cell proliferation and cytokine production, affecting immune mechanisms where VSTM4 is a participant. Lastly, wogonin can influence VSTM4's regulatory functions by modulating GABA receptors, which are known to affect cytokine production and immune cell responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palmitoleic acid | 373-49-9 | sc-205424 sc-205424A sc-205424B sc-205424C sc-205424D | 100 mg 500 mg 1 g 5 g 10 g | $33.00 $135.00 $238.00 $1039.00 $1907.00 | 4 | |
Palmitoleic acid is a fatty acid that can inhibit VSTM4 by incorporating into cell membranes and potentially altering membrane fluidity and receptor signaling. VSTM4 is implicated in immune regulation, and the altered membrane dynamics could inhibit VSTM4-mediated signaling. | ||||||
Glycyrrhizic acid | 1405-86-3 | sc-279186 sc-279186A | 1 g 25 g | $57.00 $333.00 | 7 | |
Glycyrrhizin is a triterpenoid compound that inhibits VSTM4 by inhibiting HMGB1, which is involved in the inflammatory response. Since VSTM4 is associated with immune modulation, inhibiting HMGB1 can suppress the inflammatory pathways VSTM4 is implicated in. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is a sesquiterpene lactone that inhibits VSTM4 by blocking NF-κB activation, which plays a role in immune response regulation. Since VSTM4 is involved in immune functions, inhibiting NF-κB can reduce VSTM4-mediated signal transduction. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate is a polyphenol that inhibits VSTM4 by inhibiting the activation of T-cells and the production of cytokines, which are part of the immune response in which VSTM4 is involved. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide is a diterpenoid compound that inhibits VSTM4 by inhibiting NF-κB signaling, which is involved in regulating inflammation and immune responses, processes in which VSTM4 participates. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a polyphenolic compound that can inhibit VSTM4 by suppressing the activation of NF-κB and the production of pro-inflammatory cytokines, thus potentially inhibiting the immune modulatory functions of VSTM4. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a stilbenoid that inhibits VSTM4 by modulating sirtuin activity, which can influence NF-κB signaling pathways, thereby affecting the immune regulatory functions of VSTM4. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that inhibits VSTM4 by inhibiting phosphatidylinositol 3-kinase (PI3K), which is involved in cell survival signals that can indirectly impact the regulatory roles of VSTM4 in immune responses. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that inhibits VSTM4 by inhibiting tyrosine kinases, which are involved in various signaling pathways, including those regulating immune responses where VSTM4 has a role. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is a flavone that inhibits VSTM4 by modulating various signaling pathways, including those mediated by NF-κB, impacting the immune regulatory functions of VSTM4. | ||||||