VSTM4 Activators
VSTM4 Activators encompass a range of chemical compounds that indirectly enhance the functional activity of VSTM4 through modulation of various cellular signaling pathways. For instance, Forskolin and IBMX, by increasing intracellular cAMP levels, indirectly boost VSTM4's activity by amplifying PKA-mediated signaling, which can phosphorylate substrates potentially associated with VSTM4's immune-modulatory functions. PMA, as a PKC activator, and Sphingosine-1-phosphate, through G protein-coupled receptor signaling, both contribute to the activation of phospholipase C, leading to downstream effects that can enhance VSTM4 activity in immune cell signaling. Rolipram's PDE4 inhibition also raises cAMP levels, reinforcing PKA activity and thus, can indirectly influence VSTM4's functional activity within its signaling pathways. LY294002, a PI3K inhibitor, can alter the balance of cell signaling networks, indirectly enhancing the activity of VSTM4 by influencing interrelated pathways. U0126's selective inhibition of MEK1/2 shifts the signaling equilibrium, potentially augmenting the activity of VSTM4 in alternative pathways that become more prominent when the MAPK pathway is inhibited.
The alteration of intracellular calcium dynamics through compounds like A23187 and Thapsigargin serves as another mechanism for indirectly enhancing VSTM4 function, as calcium-dependent signaling is crucial for various cellular processes, including those regulated by VSTM4. A23187, by acting as an ionophore, and Thapsigargin, by inhibiting the SERCA pump, both raise cytosolic calcium levels, thus potentiating the activation of calcium-dependent pathways that VSTM4 may modulate.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate various proteins. This cascade can enhance the activity of VSTM4 by promoting cAMP-dependent signaling pathways, which may facilitate the functions associated with VSTM4 in immune response modulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol (DAG) analog that activates protein kinase C (PKC). PKC activation can lead to the phosphorylation of proteins involved in the signaling pathways that VSTM4 is a part of, thus indirectly increasing VSTM4 functional activity by enhancing signaling through pathways VSTM4 is involved in. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P binds to its G protein-coupled receptors, initiating signaling pathways that can lead to the activation of phospholipase C and subsequent PKC activation. By modulating such signaling pathways, S1P can enhance the activity of VSTM4 by influencing signaling cascades that VSTM4 may regulate or be involved in, particularly in immune cell function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP. By increasing levels of these cyclic nucleotides, IBMX can enhance PKA and PKG activity, respectively. This can lead to the activation of downstream signaling molecules and enhance the functions of VSTM4 indirectly by promoting signaling pathways in which VSTM4 may play a role. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased cAMP levels in cells. This elevation can enhance PKA activity, which may influence signaling pathways involving VSTM4, thereby indirectly enhancing VSTM4's functional activity by promoting signaling through pathways VSTM4 is involved in. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, it prevents the activation of Akt signaling, which can lead to alterations in downstream signaling networks. This modulation can indirectly enhance VSTM4 activity by affecting signaling pathways where VSTM4 might be implicated, particularly in the regulation of immune cell signaling. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, which can activate calcium-dependent signaling pathways. This activation can enhance the activity of VSTM4 indirectly by promoting signaling pathways that VSTM4 is involved in, especially in immune cell function where calcium signaling plays a crucial role. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to increased cytosolic calcium levels by preventing the reuptake of calcium into the sarcoplasmic/endoplasmic reticulum. Elevated calcium can activate numerous calcium-dependent signaling pathways, potentially enhancing the functional activity of VSTM4 by modulating signaling pathways that involve calcium signaling where VSTM4 may play a role. | ||||||