Molecular structure of Glycyrrhizic acid, CAS Number: 1405-86-3
Glycyrrhizic acid (CAS 1405-86-3)
See product citations (7)
Application:
Glycyrrhizic acid is a triterpene saponin
CAS Number:
1405-86-3
Molecular Weight:
822.93
Molecular Formula:
C42H62O16
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Glycyrrhizic acid shows anti-inflammatory, antiulcerous and antiallergic effects. Glycyrrhizic acid is an inhibitor of 11 beta-HSD. It is believed that glycyrrhizic acid may act by modulating the expression of various genes involved in inflammation and cell proliferation. In addition, glycyrrhizic acid may act by inhibiting the activity of enzymes involved in the metabolism of lipids and carbohydrates, as well as by binding to certain receptors on the surface of cells.
Glycyrrhizic acid (CAS 1405-86-3) References
- Glycyrrhizin represses total parenteral nutrition-associated acute liver injury in rats by suppressing endoplasmic reticulum stress. | Tsai, JJ., et al. 2013. Int J Mol Sci. 14: 12563-80. PMID: 23771023
- Comparison of the exposure of glycyrrhizin and its metabolites and the pseudoaldosteronism after intravenous administration of alpha- and beta-glycyrrhizin in rat. | Xu, R., et al. 2013. Drug Res (Stuttg). 63: 620-4. PMID: 23864391
- Improving the thrombin inhibitory activity of glycyrrhizin, a triterpenic saponin, through a molecular simplification of the carbohydrate moiety. | de Paula, FT., et al. 2013. Chem Biol Drug Des. 82: 756-60. PMID: 23964664
- Iontophoretic transdermal delivery of glycyrrhizin: effects of pH, drug concentration, co-ions, current intensity, and chemical enhancers. | Yamamoto, R., et al. 2013. Chem Pharm Bull (Tokyo). 61: 1275-81. PMID: 24292789
- Effect of glycyrrhizin on traumatic brain injury in rats and its mechanism. | Gu, XJ., et al. 2014. Chin J Traumatol. 17: 1-7. PMID: 24506915
- A simple semi-preparative reversed-phase HPLC/PDA method for separation and quantification of glycyrrhizin in nine samples of Glycyrrhiza glabra root collected from different geographical origins. | Basar, N., et al. 2014. Phytochem Anal. 25: 399-404. PMID: 24585378
- Glycyrrhizin inhibits the inflammatory response in mouse mammary epithelial cells and a mouse mastitis model. | Fu, Y., et al. 2014. FEBS J. 281: 2543-57. PMID: 24698106
- Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1. | Kim, YM., et al. 2015. Int Immunopharmacol. 26: 112-8. PMID: 25812767
- Potential drug interactions associated with glycyrrhizin and glycyrrhetinic acid. | Feng, X., et al. 2015. Drug Metab Rev. 47: 229-38. PMID: 25825801
- Glycyrrhizin Attenuates Proinflammatory Cytokines through a Peroxisome Proliferator-Activated Receptor-γ-Dependent Mechanism and Experimental Vasospasm in a Rat Model. | Chang, CZ., et al. 2015. J Vasc Res. 52: 12-21. PMID: 25896311
- [Effects of combination of glycyrrhizin acid, ligustrazine and puerarin on LPS-induced cytokines expression in macrophage]. | Liu, Z., et al. 2015. Zhongguo Zhong Yao Za Zhi. 40: 4068-74. PMID: 27062829
- Simultaneous HPLC analysis, with isocratic elution, of glycyrrhizin and glycyrrhetic acid in liquorice roots and confectionery products | Cesare Sabbioni, et al. 2006. Phytochemical Analysis. 25-31.
- Antiviral effects of Glycyrrhiza species | Cristina Fiore, et al. 2008. Phytotherapy Research. 141-148.
Inhibitor of:
β-defensin 128, β-defensin 130, β-defensin 4, γENaC, 11 beta-HSD, alpha-L-iduronidase, CLEC-4D, COLEC10, cryptdin 21, DC-SIGN/CD209, DD1, EG210155, Gram Negative Endotoxin Marker, HAPLN4, HCAM, HMG-1, HMG-20A, HYAL2, IL-1F10, IRF-1, IRF-3, ITIH (Inter-alpha-trypsin inhibitor), Laminin β-1, LCE1E, LCE2D, LL-37, LOC150356, MD-2, MMP-7, NFATc4, OATP1, Oval Cell Marker, Polyoma virus VP1, SCARF (scavenger receptor class F), SPACA3, SPLUNC2, TRβ, TRIM56, VP16, and VSTM4.Activator of:
α-defensin 4, β-defensin 108B, 11β-HSD2, AKR1C12, Aldosterone, ANG I, ATP10A, C4BPβ, C6, CD177, CD200R3, connexin 30, connexin 46, connexin 59, EG435927, Embigin, ficolin B, galectin-8, HLA-G, HYAL3, IFN-α4, IFN-α7, Integrin αL, L-ficolin, LEKTI, LOXL1, LSECtin, MBL-C, MRP-S11, NKG2-E, OCT1, OTTMUSG00000018260, RAET1G, RLD-1, Sciellin, SPANX-N4, T2R6, TGase3, TGR5, and TREM-2b.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Glycyrrhizic acid, 1 g | sc-279186 | 1 g | $56.00 | |||
Glycyrrhizic acid, 25 g | sc-279186A | 25 g | $326.00 |