VSTM2A Inhibitors
Chemical inhibitors of VSTM2A can interfere with the regulation of gene expression by targeting various mechanisms of epigenetic modification. Agents such as 5-Azacytidine and Decitabine function as DNA methyltransferase inhibitors, acting to induce a state of DNA hypomethylation which can lead to the upregulation of gene expression. When DNA methylation is inhibited, genes that were previously silenced may become active, altering the protein landscape within the cell. This change in gene expression can result in the functional inhibition of VSTM2A by increasing the production of other proteins that compete with or counteract its function. Similarly, RG108, by targeting the same enzymatic process, can disrupt the normal pattern of gene silencing and activation which is crucial for the proper functioning of VSTM2A within its regulatory network.
On another front, histone deacetylase inhibitors such as Trichostatin A, SAHA (Vorinostat), Mocetinostat, Entinostat, Romidepsin, and Panobinostat can modify chromatin structure, leading to a more relaxed and transcriptionally active chromatin state. By increasing histone acetylation levels, these compounds can facilitate the transcription of genes that either encode for regulatory proteins that intersect with the functional pathway of VSTM2A or directly regulate the expression of VSTM2A itself. In addition, BIX-01294 and UNC0638, by inhibiting histone methyltransferase enzymes such as G9a, can alter the methylation status of histones, further influencing the transcriptional landscape in a manner that affects the function of VSTM2A. GSK343, as an EZH2 methyltransferase inhibitor, can also change the methylation pattern of histones, which may lead to changes in gene expression that impact the activity of VSTM2A. Together, these chemical inhibitors can alter the epigenetic regulation and modify the protein-protein interactions or signaling pathways that are necessary for the normal functioning of VSTM2A.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a nucleoside analog of cytidine, can inhibit DNA methyltransferases, which could lead to hypomethylation of DNA and affect the expression of various genes, including VSTM2A, by altering chromatin structure and gene transcription regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can alter chromatin structure and gene expression patterns. By affecting acetylation levels, it could impact the expression and function of proteins involved in the same pathways as VSTM2A, thereby leading to functional inhibition. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA, like Trichostatin A, is a histone deacetylase inhibitor that can change the chromatin landscape and potentially influence the expression and function of proteins that interact or are co-regulated with VSTM2A, resulting in its functional inhibition. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is another DNA methyltransferase inhibitor which, by preventing DNA methylation, could disrupt the transcriptional regulation of genes that are involved in the same pathways or regulatory networks as VSTM2A, thus possibly leading to its functional inhibition. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 is an inhibitor of G9a histone methyltransferase that could impact histone methylation status, potentially altering the expression and function of proteins in the same pathway as VSTM2A, leading to its inhibition. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat is a histone deacetylase inhibitor that could modify the expression and function of proteins that are involved in the same biological processes as VSTM2A, potentially resulting in the functional inhibition of VSTM2A. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a DNA methyltransferase inhibitor that induces hypomethylation of DNA. It could influence gene expression patterns in a way that would lead to the functional inhibition of proteins linked with VSTM2A. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Entinostat is a benzamide histone deacetylase inhibitor that could affect the acetylation levels of histones associated with genes that are co-regulated with or are part of the same signaling pathways as VSTM2A, potentially leading to its functional inhibition. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin is a cyclic peptide that inhibits histone deacetylase, which could result in altered gene expression and potentially affect proteins that are involved in the same pathways as VSTM2A, leading to functional inhibition of VSTM2A. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a potent histone deacetylase inhibitor that could disrupt the expression and function of proteins that are in the same pathway as VSTM2A, potentially leading to the functional inhibition of VSTM2A. | ||||||