VPS36 Activators
VPS36 (Vacuolar Protein Sorting-associated protein 36) is an integral component of the ESCRT-II complex (Endosomal Sorting Complex Required for Transport II), which is essential for the sorting of ubiquitinated membrane proteins into the internal vesicles of multivesicular bodies (MVBs). This process is critical for the downregulation of surface receptors and the trafficking of membrane proteins to the lysosome for degradation.The ESCRT-II complex, including VPS36, is involved in the recognition and sequestration of ubiquitinated proteins into the endosomal membrane. VPS36 specifically binds to ubiquitin via its GLUE (GRAM-like ubiquitin-binding in Eap45) domain, which is a unique feature distinguishing it from other ESCRT components. This interaction is pivotal for the sorting function of ESCRT-II.
VPS36 is also implicated in the late stages of cytokinesis and in the abscission process, where the final separation of the daughter cells occurs following mitosis. Additionally, it plays a role in the replication and pathogenesis of various viruses, as many viruses hijack the ESCRT machinery to bud from the host cell membrane.Dysfunction in the ESCRT machinery, including VPS36, can lead to diseases such as neurodegenerative disorders, cancer, and viral infections. The precise regulation of VPS36 and the ESCRT-II complex is therefore crucial for maintaining cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that could lead to the accumulation of ubiquitinated proteins, potentially increasing VPS36 expression for enhanced protein sorting. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
An inhibitor of the vacuolar H+ ATPase that can affect endosomal acidification and may upregulate VPS36 as a compensatory mechanism. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
A selective proteasome inhibitor that may induce the expression of proteins involved in ubiquitin-proteasome pathways, including VPS36. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Known to inhibit lysosomal function, which could lead to altered endosomal sorting and potentially increase VPS36 expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Induces ER stress and could upregulate VPS36 as part of the unfolded protein response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Another ER stress inducer that may enhance the expression of proteins involved in vesicular trafficking, such as VPS36. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Affects gene expression and differentiation, potentially influencing the expression of proteins involved in endocytic sorting. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Has been shown to modulate autophagy and could potentially affect the expression of proteins involved in the endocytic pathway. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
An autophagy inhibitor that may impact vesicular trafficking pathways and influence VPS36 expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
By inhibiting GSK-3, it may affect signaling pathways that regulate protein sorting and turnover, potentially influencing VPS36 expression. | ||||||