VMP1 inhibitors constitute a specialized class of chemical compounds that have gained prominence in the field of cellular biology and autophagy research. VMP1, or Vacuole Membrane Protein 1, is a protein that plays a pivotal role in the regulation of autophagy, a cellular process responsible for degrading and recycling cellular components to maintain cellular homeostasis and respond to various stress conditions. The term VMP1 inhibitors refers to a group of molecules meticulously designed to selectively target and modulate the activity of VMP1. These inhibitors serve as invaluable tools in laboratory investigations, enabling researchers to explore the intricate molecular functions and cellular processes associated with VMP1.
VMP1 inhibitors typically function by interfering with the role of VMP1 in the initiation and formation of autophagic structures, such as autophagosomes, which are essential for the sequestration and degradation of cellular cargo. This interference can disrupt the normal process of autophagy, impacting various aspects of cellular quality control, stress response, and adaptation. Researchers employ VMP1 inhibitors to gain insights into the physiological roles and molecular interactions of VMP1 within cells, aiming to advance our understanding of the fundamental mechanisms involved in autophagy regulation. Through the study of VMP1 inhibitors, scientists seek to unravel the complexities of cellular self-cleaning processes, cellular responses to stress, and the broader field of cell biology, contributing to our knowledge of how cells maintain their health and adapt to changing environmental conditions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that might downregulate signaling pathways leading to reduced VMP1 expression as part of modulating autophagy. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that could inhibit autophagy and consequently affect VMP1 expression indirectly. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
3-Methyladenine (3-MA) inhibits autophagy by blocking PI3K, potentially leading to decreased expression of autophagy-related proteins. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 inhibits mTOR, which is a central regulator of autophagy, possibly impacting VMP1 expression as part of this process. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
Spautin-1 promotes the degradation of autophagy-related proteins and might affect VMP1 levels indirectly. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine inhibits autophagy by preventing endosomal acidification, which might indirectly reduce VMP1 expression. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 inhibits the vacuolar ATPase and autophagy, potentially affecting VMP1 expression by inhibiting autophagosome maturation. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
Hydroxychloroquine impairs endosomal acidification and autophagy, potentially influencing VMP1 expression as well. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $30.00 $125.00 $445.00 | 45 | |
This compound inhibits p38 MAPK and could modulate stress responses and autophagy, possibly impacting VMP1 expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that could affect signaling pathways regulating autophagy and VMP1 expression. | ||||||