Date published: 2025-12-22

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Vmn1r209 Inhibitors

Vmn1r209 is a member of the V1R family of receptors, which are typically involved in pheromone detection and associated with the vomeronasal organ (VNO) in many animals. These receptors play a critical role in social and reproductive behaviors by detecting specific chemical signals. The precise function of Vmn1r209 in sensory perception, particularly in the context of pheromone detection, is a key aspect of its biological significance. Inhibiting Vmn1r209 requires an understanding of the various signaling pathways and molecular interactions that regulate its expression and function. The selected inhibitors target multiple pathways that could be involved in the regulation of Vmn1r209, including MAP kinase pathways (p38, JNK, ERK), PI3K/Akt pathway, and other mechanisms related to cellular metabolism and stress responses. Inhibitors like LY294002 and Wortmannin, which target the PI3K/Akt pathway, are significant due to the pathway's broad role in cell survival, growth, and metabolism. Their inhibition could have downstream effects on Vmn1r209 expression, particularly in sensory neurons where this pathway plays a crucial role. SB203580, U0126, and PD98059, which target MAP kinase pathways, are essential in understanding the gene's regulation in the context of environmental and stress-related signals. These pathways are often involved in converting external stimuli into cellular responses, and their modulation could influence Vmn1r209 expression in sensory perception processes. Rapamycin and Bafilomycin A1 highlight the importance of cellular growth mechanisms and lysosomal function in regulating Vmn1r209. By affecting mTOR signaling and lysosomal acidification, these inhibitors could indirectly influence Vmn1r209 expression, especially if the gene is involved in pathways related to cell growth and lysosomal function in sensory neurons. Other inhibitors, such as SP600125, Genistein, Curcumin, Dorsomorphin, and Resveratrol, offer insights into the potential role of Vmn1r209 in processes modulated by JNK, tyrosine kinases, inflammatory pathways, cellular energy metabolism, and epigenetic mechanisms. These inhibitors demonstrate the diverse mechanisms through which Vmn1r209 can be modulated, reflecting the complexity of its regulation in sensory perception and pheromone detection. In summary, the exploration of Vmn1r209 inhibition is crucial for understanding its role in sensory biology and animal behavior. The inhibitors identified provide a comprehensive view of the potential mechanisms for modulating Vmn1r209, offering a foundation for further research into this gene's function in sensory perception and pheromone detection.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002, a PI3K inhibitor, hinders the PI3K/Akt pathway, crucial in various cellular processes. This inhibition may indirectly suppress Vmn1r209 by disrupting signaling pathways that regulate its expression in sensory neurons.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

SB203580 is a p38 MAP kinase inhibitor, known to affect inflammatory responses. Inhibiting p38 MAP kinase could reduce Vmn1r209 expression by attenuating signaling pathways involved in inflammation, potentially influencing its role in sensory perception.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

U0126, a MEK inhibitor, targets the ERK pathway. This inhibition may lead to a decrease in Vmn1r209 expression if the gene is involved in cellular responses mediated by the ERK pathway, particularly in sensory neurons.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin, a potent PI3K inhibitor, can disrupt various signaling pathways, including those related to sensory perception. This broad inhibition could lead to decreased Vmn1r209 expression if it is regulated by PI3K-dependent pathways.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

PD98059, a MEK inhibitor, disrupts the MAPK/ERK pathway. This action can potentially downregulate Vmn1r209 expression by interfering with pathways involved in sensory processing.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Rapamycin, an mTOR inhibitor, affects cell growth and proliferation. Inhibiting mTOR could lead to decreased Vmn1r209 expression, especially if the gene is involved in pathways related to cell growth and sensory neuron function.

Bafilomycin A1

88899-55-2sc-201550
sc-201550A
sc-201550B
sc-201550C
100 µg
1 mg
5 mg
10 mg
$96.00
$250.00
$750.00
$1428.00
280
(6)

Bafilomycin A1, an inhibitor of vacuolar-type H+-ATPase, can disrupt lysosomal acidification. This might reduce Vmn1r209 expression if the gene is involved in processes influenced by lysosomal function, possibly in sensory neurons.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125, a JNK inhibitor, targets the JNK pathway, affecting stress responses. By inhibiting JNK signaling, SP600125 might indirectly suppress Vmn1r209 expression, assuming the gene is regulated by stress or inflammatory signals.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein, a tyrosine kinase inhibitor, impacts cellular signaling pathways including those in sensory or neuronal cells. This could lead to indirect suppression of Vmn1r209 if its expression is regulated by tyrosine kinase-dependent pathways.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin, known for its anti-inflammatory properties, modulates various signaling pathways. This modulation could affect Vmn1r209 expression, especially if the gene is responsive to inflammatory or stress-related signals.