Vmn1r129 Activators
Vmn1r129, a vomeronasal receptor, holds a significant role in chemosensory signal transduction within the vomeronasal organ. The receptor is predicted to be involved in detecting specific chemical cues, contributing to the intricate communication system associated with social and reproductive behaviors in various species. Vmn1r129's function is intricately linked to its expression levels, which are modulated by a diverse array of chemical activators. These activators, outlined in the table, exert their influence through both direct and indirect mechanisms.
The direct activators, such as Retinoic Acid, Chrysin, and Trichostatin A, directly impact the expression of Vmn1r129 by influencing chromatin accessibility and histone modifications crucial for gene transcription. Indirect activators, like Forskolin, Lithium Chloride, and SB-431542, modulate cellular signaling pathways involved in the receptor's expression and function. The interplay of these activators affects cAMP-dependent pathways, Wnt signaling, and histone acetylation, collectively contributing to the regulation of Vmn1r129 activation. The complexity of these mechanisms highlights the sophisticated control systems governing the expression and responsiveness of Vmn1r129 in the context of vomeronasal signal transduction. The intricate dance of biochemical events orchestrated by these activators underlines the crucial role of Vmn1r129 in decoding chemical cues and mediating behavioral responses in the context of olfactory communication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Functions as a direct activator by up-regulating Vmn1r129 through the retinoic acid signaling pathway, influencing cellular processes essential for the receptor's expression and function. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Acts as a direct activator by promoting the expression of Vmn1r129 through its influence on histone acetylation, affecting chromatin accessibility in regions associated with the receptor gene. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Up-regulates Vmn1r129 expression indirectly by inhibiting GSK-3β, leading to the stabilization of β-catenin and subsequent modulation of Wnt signaling pathways involved in receptor activation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Indirectly influences Vmn1r129 activation by inhibiting TGF-β receptors, thereby modulating cellular processes related to the expression and function of the receptor in vomeronasal signal transduction. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates Vmn1r129 indirectly through sirtuin-mediated pathways, influencing cellular events that contribute to the receptor's expression and responsiveness in vomeronasal signal transduction. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Inhibits the MEK-ERK pathway, indirectly enhancing Vmn1r129 expression by preventing negative feedback mechanisms, allowing sustained signaling crucial for the receptor's activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Indirectly impacts Vmn1r129 by inhibiting PI3-kinase, modulating pathways associated with cellular processes crucial for the receptor's expression and function in vomeronasal signal transduction. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Modifies chromatin accessibility by inhibiting bromodomain proteins, directly influencing Vmn1r129 expression and responsiveness in vomeronasal signal transduction pathways. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
Indirectly activates Vmn1r129 by inhibiting BMP signaling, modulating cellular events involved in receptor expression and function within the vomeronasal system. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Acts as a direct activator by inhibiting HDACs, leading to increased histone acetylation and enhanced Vmn1r129 expression, crucial for the receptor's responsiveness in vomeronasal signal transduction. | ||||||