Vmn1r129 Inhibitors
Vmn1r129, a member of the vomeronasal 1 receptor family, is implicated in chemosensory perception within the vomeronasal system. As a receptor expressed in the vomeronasal organ, it plays a crucial role in detecting pheromones and other chemosensory cues involved in social and reproductive behaviors. The predicted functions include the recognition of specific molecular signals that trigger neural responses associated with mating and territorial behaviors. Inhibition of Vmn1r129 involves targeting various signaling pathways and cellular processes crucial for its chemosensory functions. Chemical inhibitors, such as Tetrodotoxin, U73122, Lidocaine, Wortmannin, CNQX, Cycloheximide, SCH23390, Bay K8644, Pertussis toxin, Flupirtine, PD98059, and BAPTA-AM, act through diverse mechanisms, including modulation of ion channels, inhibition of enzyme activities, and interference with receptor-mediated signaling. These inhibitors have the potential to disrupt the intricate processes involved in Vmn1r129 activation, reception, and transduction of chemosensory signals.
The general mechanisms of inhibition highlight the complexity of vomeronasal signal transduction, involving ion channels, G protein-coupled receptors, and downstream signaling pathways. The diverse approaches to inhibition underscore the importance of these regulatory processes in the context of chemosensory perception. As our understanding of the vomeronasal system advances, these inhibitors serve as valuable tools for dissecting the molecular and cellular mechanisms underlying Vmn1r129-mediated behaviors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $51.00 $131.00 | ||
Lidocaine acts as a local anesthetic by inhibiting voltage-gated sodium channels. Its impact on neuronal excitability may indirectly influence Vmn1r129-mediated signaling, potentially altering the reception and processing of chemosensory stimuli within the vomeronasal system. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin inhibits phosphoinositide 3-kinase (PI3K), impacting cellular signaling cascades. Its influence on PI3K pathways may indirectly disrupt Vmn1r129 function, potentially altering the cellular processes associated with vomeronasal signal transduction and chemosensory perception. | ||||||
6-Cyano-7-nitroquinoxaline-2,3-dione | 115066-14-3 | sc-505104 | 10 mg | $208.00 | 2 | |
CNQX inhibits ionotropic glutamate receptors, potentially affecting synaptic transmission within the vomeronasal circuit. Its impact on glutamate signaling may indirectly modulate Vmn1r129 responses, influencing the processing of chemosensory stimuli and subsequent neural signaling in the vomeronasal system. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits protein synthesis, potentially affecting the production of proteins involved in Vmn1r129 signaling pathways. Its impact on cellular protein synthesis may indirectly influence the expression and function of Vmn1r129, altering chemosensory perception within the vomeronasal system. | ||||||
SCH 23390 | 125941-87-9 | sc-200408 sc-200408A | 5 mg 25 mg | $179.00 $733.00 | 2 | |
SCH23390 is a dopamine receptor antagonist, potentially influencing dopaminergic modulation of vomeronasal responses. Its action on dopamine receptors may indirectly impact Vmn1r129-mediated signaling, altering the neuromodulatory processes associated with chemosensory perception in the vomeronasal system. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K8644 enhances L-type calcium channel activity, potentially influencing calcium-dependent signaling pathways associated with Vmn1r129 function. Its impact on calcium channels may indirectly modulate the reception and transduction of vomeronasal signals, affecting chemosensory perception within the vomeronasal system. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis toxin inhibits Gαi protein signaling, potentially disrupting G protein-coupled receptor (GPCR) pathways, including those linked to Vmn1r129. Its impact on Gαi proteins may indirectly influence vomeronasal signal transduction, altering chemosensory perception mediated by Vmn1r129. | ||||||
Flupirtine Maleate | 75507-68-5 | sc-218512 | 10 mg | $103.00 | 1 | |
Flupirtine activates potassium channels, potentially influencing neuronal excitability in vomeronasal circuits. Its action on potassium channels may indirectly modulate Vmn1r129-mediated signaling, impacting the processing of chemosensory stimuli within the vomeronasal system. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 inhibits MEK in the MAPK/ERK signaling pathway, potentially affecting downstream signaling linked to Vmn1r129 activation. Its impact on the MAPK/ERK pathway may indirectly influence Vmn1r129 function, altering the cellular processes associated with vomeronasal signal transduction and chemosensory perception. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a calcium chelator, potentially impacting calcium-dependent signaling pathways associated with Vmn1r129 activation. Its ability to chelate calcium ions may indirectly disrupt vomeronasal signal transduction, influencing the reception and processing of chemosensory stimuli mediated by Vmn1r129. | ||||||