Lidocaine CAS: 137-58-6
MF: C14H22N2O
MW: 234.34
A selective inverse peripheral histamine H1-receptor agonist.

Lidocaine (CAS 137-58-6)

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Application: A selective inverse peripheral histamine H1-receptor agonist
CAS Number: 137-58-6
Purity: ≥98%
Molecular Weight: 234.34
Molecular Formula: C14H22N2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Lidocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Lidocaine is also an anasthetic and class Ib antiarrhythmic agent. This compund is known to block voltage-gated sodium channels in the inactivated state. Lidocaine is a second-generation antihistamine agent closely structurally related to tricyclic antidepressants such as imipramine, and distantly related to the atypical antipsychotic quetiapine, used to treat allergies.


References

Sarraf et al (2003) Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats. Br.J.Pharmacol. 139 1389.

Physical State :
Solid
Solubility :
Soluble in ethanol (50 mg/ml), water (9 mg/ml at 25° C), methanol, DMSO (47 mg/ml at 25° C), and chloroform.
Storage :
Store at room temperature
Melting Point :
65-69° C
Boiling Point :
~350.8° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 10 µM; Histamine H1-receptor: IC50 = >32 µM; Na+ CP type Vα: IC50 = 108 µM (human); HERG: IC50 = 0.26 mM (human)
pK Values :
pKa: 8.01, pKb: 7.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AN7525000
PubChem CID :
3676
Merck Index :
14: 5482
MDL Number :
MFCD00026733
EC Number :
205-302-8
Beilstein Registry :
2215784
SMILES :
CCN(CC)CC(=O)NC1=C(C=CC=C1C)C

Download SDS (MSDS)

Certificate of Analysis

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