VIP36 Activators
VIP36 activators are a class of chemical compounds that have garnered attention in the field of cellular biology and molecular research due to their unique ability to modulate the function of VIP36, also known as LMAN1 (Lectin, Mannose-Binding, 1). VIP36 is a type I transmembrane protein primarily found in the endoplasmic reticulum (ER) and the Golgi apparatus of cells. It plays a crucial role in the sorting and trafficking of glycoproteins, particularly those containing mannose residues. VIP36 is responsible for recognizing mannose-containing glycoproteins and facilitating their transport from the ER to the Golgi apparatus for further processing and maturation.
VIP36 activators are synthetic or naturally occurring molecules that interact with VIP36 to enhance its function. These activators are designed to bind to specific regions of VIP36, resulting in increased mannose-binding capacity or improved efficiency in the glycoprotein trafficking process. This modulation of VIP36 activity can have significant implications in research related to glycoprotein processing, protein folding, and quality control within the secretory pathway of cells. By manipulating VIP36 function, scientists aim to gain a deeper understanding of the intricate mechanisms governing protein trafficking in cells, which can provide valuable insights into various cellular processes and diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to increased levels of cyclic AMP (cAMP). Elevated cAMP can activate PKA, which may phosphorylate VIP36, thereby potentially enhancing its lectin activity and its role in quality control of glycoprotein folding. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. This rise in calcium can activate calmodulin-dependent kinases, which could then phosphorylate VIP36, affecting its intracellular trafficking and carbohydrate-binding activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
As a PKC activator, PMA can stimulate protein kinase C, which may lead to the phosphorylation of VIP36. This phosphorylation could enhance the protein's ability to mediate the transport of glycoproteins. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
This cAMP analog can activate protein kinase A (PKA) and mimic the effects of cAMP in cells. Activation of PKA could result in the phosphorylation of VIP36, increasing its functionality in glycoprotein sorting. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, which prevents the dephosphorylation of proteins. Inhibition of these phosphatases could lead to an accumulation of phosphorylated VIP36, thereby enhancing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to have multiple effects on cellular signaling pathways, including inhibition of certain protein kinases. This could shift the balance of kinase activity in favor of the pathways that activate VIP36, enhancing its role in glycoprotein trafficking. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Similar to okadaic acid, Calyculin A is an inhibitor of protein phosphatases. By inhibiting PP1 and PP2A, it could maintain VIP36 in a phosphorylated state, which is often associated with enhanced activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, potentially influencing calcium-dependent proteins that interact with or modify VIP36, resulting in its enhanced functional activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is an inhibitor of protein synthesis and also activates stress-activated protein kinases (SAPKs). Activation of SAPKs could lead to phosphorylation events that enhance the function of VIP36. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that could lead to the accumulation of misfolded glycoproteins. This accumulation may increase the demand for VIP36 function in quality control of glycoprotein folding and transport. | ||||||