VIP36 Antibody (264C4a): sc-130026

VIP36 Antibody (264C4a) is a mouse monoclonal IgG2a antibody that detects VIP36 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). VIP36 (264C4a) antibody is available as a non-conjugated anti-VIP36 antibody. VIP36 protein, also known as lectin mannose-binding 1, plays a crucial role in the early secretory pathway by functioning as an intracellular lectin that facilitates selective transport of newly synthesized glycoproteins from the endoplasmic reticulum to the endoplasmic reticulum-Golgi intermediate compartment. VIP36 is essential for sorting and transport of glycoproteins that carry high mannose-type glycans, ensuring these molecules reach their correct destinations within the cell. Additionally, VIP36 interacts with ERGIC-53, another mannose-specific lectin, which recognizes specific sugar residues on glycoproteins and glycolipids, mediating their sorting and recycling. Proper functioning of VIP36 and its interactions are vital for maintaining cellular homeostasis, and any disruption in this process can lead to significant cellular dysfunction. Notably, a null expression of ERGIC-53, also designated LMAN1, is associated with a rare autosomal recessive bleeding disorder characterized by a combined deficiency of coagulation factors V and VIII, highlighting the importance of these proteins in health and disease.

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VIP36 Antibody (264C4a) References:

1. VIP36 localisation to the early secretory pathway.  |  Füllekrug, J., et al. 1999. J Cell Sci. 112 (Pt 17): 2813-21. PMID: 10444376
2. Involvement of VIP36 in intracellular transport and secretion of glycoproteins in polarized Madin-Darby canine kidney (MDCK) cells.  |  Hara-Kuge, S., et al. 2002. J Biol Chem. 277: 16332-9. PMID: 11872745
3. Lectins and protein traffic early in the secretory pathway.  |  Hauri, HP., et al. 2002. Biochem Soc Symp. 73-82. PMID: 12655775
4. LMAN1 is a molecular chaperone for the secretion of coagulation factor VIII.  |  Cunningham, MA., et al. 2003. J Thromb Haemost. 1: 2360-7. PMID: 14629470
5. The binding of VIP36 and alpha-amylase in the secretory vesicles via high-mannose type glycans.  |  Hara-Kuge, S., et al. 2004. Glycobiology. 14: 739-44. PMID: 15070860
6. Sugar-binding properties of VIP36, an intracellular animal lectin operating as a cargo receptor.  |  Kamiya, Y., et al. 2005. J Biol Chem. 280: 37178-82. PMID: 16129679
7. Oligomerization and interacellular localization of the glycoprotein receptor ERGIC-53 is independent of disulfide bonds.  |  Neve, EP., et al. 2005. J Mol Biol. 354: 556-68. PMID: 16257008
8. Emp47 and Vip36 are required for polarized growth and protein trafficking between ER and Golgi apparatus in opportunistic fungal pathogen Aspergillus fumigatus.  |  Gao, L., et al. 2022. Fungal Genet Biol. 158: 103638. PMID: 34798270
9. A dual role for COOH-terminal lysine residues in pre-Golgi retention and endocytosis of ERGIC-53.  |  Kappeler, F., et al. 1994. J Biol Chem. 269: 6279-81. PMID: 8119975
10. VIP36, a novel component of glycolipid rafts and exocytic carrier vesicles in epithelial cells.  |  Fiedler, K., et al. 1994. EMBO J. 13: 1729-40. PMID: 8157011
11. ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif.  |  Schindler, R., et al. 1993. Eur J Cell Biol. 61: 1-9. PMID: 8223692
12. [VIP36 recognizes high-mannose type glycans in relation to apical membrane traffic].  |  Yamashita, K., et al. 1998. Tanpakushitsu Kakusan Koso. 43: 2455-63. PMID: 9883672

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VIP36 Antibody (264C4a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-VIP36 Antibody (264C4a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VIP36 Antibody (264C4a) Specifications

Alternate Product Name: VIP36

Product Clone Name: 264C4a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: VIP36

Epitope Species: human

Product Reactivity/Detection: VIP36

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for VIP36 Antibody (264C4a): N/A