vasostatin I Inhibitors
Vasostatin I inhibitors represent a distinctive class of chemical compounds that target and inhibit the activity of vasostatin I, a peptide derived from the larger precursor protein vasoactive intestinal peptide (VIP). Vasostatin I is a bioactive fragment with significant roles in modulating cellular and vascular functions. It is primarily involved in regulating cell proliferation, migration, and vascular tone through its interaction with specific receptors and signaling pathways. This peptide exerts its effects by binding to cellular receptors, which in turn influences various intracellular processes and cellular responses.
The mechanism of action of vasostatin I inhibitors involves binding to the vasostatin I peptide or its associated molecular partners, thereby disrupting its ability to interact with its receptors. By inhibiting these interactions, these compounds interfere with the peptide's normal biological functions, such as modulation of cell growth, adhesion, and vascular dynamics. Researchers utilize vasostatin I inhibitors to delve into the specific roles of this peptide in cellular signaling and vascular regulation, offering insights into how its inhibition affects cellular processes and vascular function. The study of these inhibitors helps in understanding the intricate mechanisms through which vasostatin I influences cellular behavior and vascular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid could downregulate vasostatin I by binding to retinoic acid receptors, which may repress the transcription of the gene encoding vasostatin I. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may decrease vasostatin I levels by inhibiting the activation of transcription factors that promote vasostatin I gene transcription. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein might reduce vasostatin I expression by blocking tyrosine kinase-dependent pathways essential for the transcription of vasostatin I's gene. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has the potential to downregulate vasostatin I expression by activating sirtuins that deacetylate histones associated with the vasostatin I gene, leading to a more condensed chromatin state and reduced transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate might decrease the expression of vasostatin I by altering DNA methylation patterns within the promoter region of the vasostatin I gene, thereby hindering its transcription. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin could downregulate vasostatin I by inhibiting specific kinase signaling cascades that are necessary for the upregulation of vasostatin I gene transcription. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $32.00 $86.00 $150.00 | 3 | |
Sulindac may contribute to the decreased expression of vasostatin I through the inhibition of cyclooxygenase enzymes, leading to a reduction in prostaglandin levels that might otherwise promote vasostatin I gene expression. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine might decrease the expression of vasostatin I by disrupting endolysosomal function, which could lead to changes in cellular signaling pathways and subsequent downregulation of vasostatin I gene transcription. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine could inhibit vasostatin I expression by antagonizing adenosine receptors, thereby altering cAMP levels and downregulating cAMP-responsive elements within the vasostatin I gene promoter. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate might reduce vasostatin I levels by inhibiting histone deacetylases, leading to hyperacetylation of histones near the vasostatin I gene and a tighter chromatin structure that is less accessible for transcription. | ||||||