VAM1 Inhibitors

VAM1 inhibitors encompass a broad spectrum of chemicals primarily targeting various cellular signaling pathways. Wortmannin and LY294002 are specific to the PI3K pathway, which is central to multiple cellular functions, including growth, proliferation, and survival. Their inhibitory action on PI3K can lead to the modulation of downstream effectors and processes.

Rapamycin specifically inhibits mTOR signaling, a pivotal regulator of cell growth, proliferation, and autophagy. On the other hand, PD98059 and U0126 focus on the MAPK signaling pathway, which governs cellular responses to growth signals. SB203580, a p38 MAPK inhibitor, and SP600125, a JNK inhibitor, both play roles in determining cellular responses to stress and inflammation. Staurosporine's broad-spectrum inhibitory activity allows it to affect a multitude of kinases, making it a versatile tool in research. Similarly, BAY 11-7082's inhibition of the NF-kB pathway has implications for inflammatory responses and cellular survival. Bortezomib's role as a proteasome inhibitor impacts protein degradation, and Alsterpaullone and ZM-447439 target the cell cycle machinery, specifically cyclin-dependent kinases and Aurora kinases, respectively.