V1RH9 Activators
Chemical activators of V1RH9 can initiate a cascade of intracellular events leading to its functional activation. Calcium chloride, for instance, raises intracellular calcium levels that serve as a secondary messenger, activating various signaling pathways that include V1RH9. Similarly, A23187, Thapsigargin, and Ionomycin act as calcium ionophores or inhibitors of calcium reuptake, causing a surge in cytosolic calcium that can activate V1RH9-associated pathways. BAY K 8644 also promotes an increase in intracellular calcium but does so specifically through the activation of L-type calcium channels. On the other hand, Nicotine stimulates nicotinic acetylcholine receptors, which results in calcium influx and subsequent activation of V1RH9. Oxytocin engages its own receptors linked to Gq proteins, prompting an elevation in calcium via the phospholipase C pathway, which in turn can activate V1RH9.
Additionally, Forskolin and Isoproterenol exert their effects by increasing cAMP levels, which activates protein kinase A (PKA). PKA then phosphorylates target proteins within the cell, a process that can lead to V1RH9 activation. IBMX works to increase cAMP levels as well, but by a different mechanism; it inhibits phosphodiesterases responsible for cAMP breakdown. The sustained levels of cAMP then activate PKA, which may phosphorylate and activate V1RH9. PMA activates protein kinase C (PKC), another kinase that phosphorylates proteins and can lead to V1RH9 activation. These diverse chemicals, through their unique mechanisms involving calcium signaling or kinase activation, can all converge on the activation of V1RH9, highlighting the complex interplay of intracellular signaling molecules in protein regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium chloride can activate V1RH9 by increasing intracellular calcium levels, which is a secondary messenger that activates various signaling pathways within the cell that V1RH9 is a part of, leading to the functional activation of V1RH9. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX increases intracellular cAMP by inhibiting phosphodiesterases that break down cAMP. Elevated cAMP levels can result in the activation of PKA, which in turn can lead to the activation of V1RH9 through phosphorylation mechanisms. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a variety of proteins. The activation of PKC can lead to the phosphorylation and functional activation of V1RH9 as part of its signaling pathway. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as a calcium ionophore, facilitating the increase of intracellular calcium levels. The elevation of calcium can activate signaling pathways that involve V1RH9, resulting in its functional activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium levels. Elevated calcium can activate V1RH9 by triggering signaling cascades that lead to its functional activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium concentrations. This rise in calcium can activate signaling pathways that include V1RH9, culminating in the functional activation of V1RH9. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
BAY K 8644 specifically activates L-type calcium channels, which leads to an increase in intracellular calcium levels. This rise in calcium can then activate V1RH9 directly through calcium-dependent signaling pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol acts as an agonist at beta-adrenergic receptors, which can increase intracellular levels of cAMP. The increase in cAMP can activate PKA, which can lead to the functional activation of V1RH9 via phosphorylation. | ||||||
Oxytocin acetate salt | 50-56-6 | sc-279938 sc-279938A sc-279938B sc-279938C sc-279938D sc-279938E | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $60.00 $180.00 $337.00 $663.00 $969.00 $1836.00 | 4 | |
Oxytocin can bind to its receptors, which are coupled to Gq proteins, leading to an increase in intracellular calcium through the phospholipase C pathway. Increased calcium levels can activate V1RH9 through downstream signaling pathways. | ||||||