V1RC27 Activators
Chemical activators of V1RC27 engage various intracellular signaling pathways to initiate the protein's phosphorylation and subsequent activation. Forskolin, by activating adenylate cyclase, increases levels of cyclic AMP within the cell. This elevation in cAMP leads to the activation of protein kinase A (PKA), which subsequently phosphorylates V1RC27. Similarly, Isoproterenol and Adrenaline, by binding to beta-adrenergic receptors, enhance the production of cAMP, thereby also activating PKA, which then acts on V1RC27. In contrast, Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC) directly, bypassing the cAMP pathway and leading to the phosphorylation of V1RC27.
Histamine and Serotonin, upon binding to their respective G-protein-coupled receptors, induce an increase in intracellular calcium through the phospholipase C pathway. Elevated calcium levels can activate calmodulin-dependent kinases, which are capable of phosphorylating V1RC27. The activation of V1RC27 by Glutamate involves receptor-mediated signaling cascades that also increase intracellular calcium concentration, engaging calcium-dependent kinases for the phosphorylation process. Capsaicin, by activating TRPV1 receptors, and Nicotine, through nicotinic acetylcholine receptors, similarly cause a calcium influx, which activates kinases that target V1RC27. In a more indirect approach, the Calcium ionophore A23187 elevates intracellular calcium, which again leads to the activation of kinases that phosphorylate V1RC27. ATP, while not an activator itself, is crucial as it donates the phosphate groups that kinases use to phosphorylate V1RC27. Finally, Oligomycin A indirectly contributes to the activation of V1RC27 by increasing cytosolic ATP levels, thus supplying kinases with the substrate needed for V1RC27's activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing levels of cyclic AMP (cAMP), which in turn activates protein kinase A (PKA). PKA phosphorylates and activates V1RC27 as part of the cAMP-dependent signaling pathway. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol binds to and activates beta-adrenergic receptors, which enhances the production of cAMP via adenylate cyclase. The increased cAMP activates PKA, leading to the phosphorylation of V1RC27. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA directly activates protein kinase C (PKC), which can phosphorylate and thereby activate V1RC27 as part of the PKC signaling pathway. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine interacts with its G-protein-coupled receptors, leading to an increase in intracellular calcium levels through the phospholipase C pathway. Elevated calcium can activate calmodulin-dependent kinases, which in turn may phosphorylate and activate V1RC27. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $116.00 $183.00 | 15 | |
Binding to its receptors, serotonin can initiate a signaling cascade that results in the release of intracellular calcium stores, eventually leading to the activation of kinases that phosphorylate and activate V1RC27. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $291.00 $566.00 | ||
Glutamate engages its receptors on the cell surface, which can lead to the activation of various intracellular signaling pathways, including those involving calcium influx. These cascades can culminate in the phosphorylation and activation of V1RC27 by calcium-dependent kinases. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin binds to and activates TRPV1 receptors, causing a calcium influx that activates downstream kinases capable of phosphorylating and activating V1RC27. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Adrenaline engages adrenergic receptors, stimulating adenylate cyclase to produce cAMP, which activates PKA. PKA then phosphorylates V1RC27, leading to its activation. | ||||||
ADP | 58-64-0 | sc-507362 | 5 g | $53.00 | ||
ATP can serve as a substrate for kinases that phosphorylate V1RC27, thereby activating the protein. Although ATP itself does not directly activate V1RC27, its role as a phosphate donor is critical for the activation process through kinase-mediated phosphorylation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore A23187 increases intracellular calcium concentration, which can activate calcium-dependent kinases. These kinases then phosphorylate and activate V1RC27. | ||||||