V-ATPase G1 Activators
V-ATPase G1 Activators is a diverse group of compounds that can indirectly activate the V-ATPase G1 subunit. These chemicals can act through various cellular mechanisms, mostly related to proton homeostasis and signaling pathways. Cyclic AMP and Forskolin, for example, stimulate adenylate cyclase activity, increasing the production of cyclic AMP, which can indirectly activate V-ATPase G1 via PKA. Furosemide, EIPA, Ouabain, Verapamil, Diltiazem, Curcumin, and Genistein function by increasing the intracellular proton concentration through different mechanisms, which can indirectly activate V-ATPase G1.
On the other hand, Bafilomycin A1, a specific inhibitor of V-ATPases, can result in V-ATPase activation through cellular adaptive responses.Resveratrol and Methazolamide, inhibitors of carbonic anhydrase, contribute to intracellular proton accumulation, which can indirectly stimulate V-ATPase G1. Despite the diverse mechanisms, these chemicals share a common feature: they can influence proton homeostasis, an essential function of V-ATPase G1. The activation of V-ATPase G1 by these chemicals underscores the pivotal role that this protein plays in maintaining cellular pH and in proton transport across the cellular membrane. While the molecular details of this activation are complex and can vary between different chemicals, the end result is an increase in V-ATPase G1 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
Adenosine 3',5'-cyclic monophosphate is a second messenger that can stimulate Protein Kinase A (PKA), which has been found to increase V-ATPase activity, potentially activating V-ATPase G1 indirectly. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $40.00 | ||
Furosemide is a loop diuretic that can inhibit the Na+/K+/2Cl- co-transporter. This inhibition can lead to an increase in intracellular proton concentration, which can indirectly activate V-ATPase G1. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin can stimulate adenylate cyclase activity, increasing the production of cyclic AMP, which can indirectly activate V-ATPase G1 via PKA. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can suppress the activity of H+/K+-ATPase, which may lead to compensatory activation of V-ATPase G1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can lead to an increase in intracellular proton concentration through the inhibition of H+/K+-ATPase, potentially activating V-ATPase G1 indirectly. | ||||||
5-(N-Ethyl-N-isopropyl)-Amiloride | 1154-25-2 | sc-202458 | 5 mg | $102.00 | 20 | |
EIPA can inhibit the Na+/H+ exchanger, which can lead to an increase in intracellular proton concentration, potentially activating V-ATPase G1 indirectly. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain is a specific inhibitor of Na+/K+-ATPase, and its inhibition can lead to intracellular proton accumulation, potentially activating V-ATPase G1 indirectly. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker. By inhibiting calcium influx, it can lead to intracellular proton accumulation, potentially activating V-ATPase G1 indirectly. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem, a calcium channel blocker similar to Verapamil, can also lead to intracellular proton accumulation, potentially activating V-ATPase G1 indirectly. | ||||||
Methazolamide | 554-57-4 | sc-235615 | 1 g | $92.00 | 3 | |
Methazolamide is a carbonic anhydrase inhibitor that can increase intracellular proton concentration, potentially activating V-ATPase G1 indirectly. | ||||||