Molecular structure of 5-(N-Ethyl-N-isopropyl)-Amiloride, CAS Number: 1154-25-2
5-(N-Ethyl-N-isopropyl)-Amiloride (CAS 1154-25-2)
See product citations (20)
Alternate Names:
EIPA
Application:
5-(N-Ethyl-N-isopropyl)-Amiloride is a selective Na+/H+ antiporter inhibitor
CAS Number:
1154-25-2
Purity:
≥98%
Molecular Weight:
299.76
Molecular Formula:
C11H18ClN7O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-(N-Ethyl-N-isopropyl)-Amiloride is often studied for its inhibitory effects on certain ion transport proteins, such as the epithelial sodium channel (ENaC) and the Na+/H+ exchanger (NHE). Researchers utilize this compound to explore the regulation of these transporters, which are critical for maintaining sodium balance and pH homeostasis in cells. In addition, 5-(N-Ethyl-N-isopropyl)-Amiloride serves as a tool in the investigation of the mechanisms of ion flux across cellular membranes, which is fundamental in understanding various physiological processes including kidney function and neuronal activity. Furthermore, this compound is used in research to probe the role of ion channels in volume regulation of cells and to gain insights into the signaling pathways that are modulated by ionic changes within the cell.
5-(N-Ethyl-N-isopropyl)-Amiloride (CAS 1154-25-2) References
- 5-(N-Ethyl-N-isopropyl)-amiloride, an Na(+)-H(+) exchange inhibitor, protects gerbil hippocampal neurons from ischemic injury. | Phillis, JW., et al. 1999. Brain Res. 839: 199-202. PMID: 10482815
- Inhibitors on an elastase-like enzyme activity catalyzing Suc-Ala-Ala-Pro-Leu-pNA amidolysis in human seminal plasma. | Matsuda, Y., et al. 2000. Arch Androl. 44: 1-9. PMID: 10690759
- 5-(N-ethyl-N-isopropyl)amiloride and mild acidosis protect cultured cerebellar granule cells against glutamate-induced delayed neuronal death. | Andreeva, N., et al. 1992. Neuroscience. 49: 175-81. PMID: 1357585
- Dual modes of 5-(N-ethyl-N-isopropyl)amiloride modulation of apical dipeptide uptake in the human small intestinal epithelial cell line Caco-2. | Kennedy, DJ., et al. 2005. Cell Mol Life Sci. 62: 1621-31. PMID: 15968466
- Effects of barium and 5-(N-ethyl-N-isopropyl)-amiloride on proximal tubule ammonia transport. | Simon, EE., et al. 1992. Am J Physiol. 262: F36-9. PMID: 1733295
- 5-(N-ethyl-N-isopropyl)-amiloride enhances SMN2 exon 7 inclusion and protein expression in spinal muscular atrophy cells. | Yuo, CY., et al. 2008. Ann Neurol. 63: 26-34. PMID: 17924536
- Role of aminopeptidase activity in the regulation of the pressor activity of circulating angiotensins. | Ahmad, S. and Ward, PE. 1990. J Pharmacol Exp Ther. 252: 643-50. PMID: 1968973
- Inhibition of Na(+)/H(+) exchanger 1 by 5-(N-ethyl-N-isopropyl) amiloride reduces hypoxia-induced hepatocellular carcinoma invasion and motility. | Yang, X., et al. 2010. Cancer Lett. 295: 198-204. PMID: 20338684
- Acidosis and 5-(N-ethyl-N-isopropyl)amiloride (EIPA) Attenuate Zinc/Kainate Toxicity in Cultured Cerebellar Granule Neurons. | Stelmashook, EV., et al. 2015. Biochemistry (Mosc). 80: 1065-72. PMID: 26547075
- Exosomal CD47 Plays an Essential Role in Immune Evasion in Ovarian Cancer. | Shimizu, A., et al. 2021. Mol Cancer Res. 19: 1583-1595. PMID: 34016744
- Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes. | Rich, DH., et al. 1984. J Med Chem. 27: 417-22. PMID: 6142952
- Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes. | Aoyagi, T., et al. 1978. J Antibiot (Tokyo). 31: 636-8. PMID: 681249
- 5-(N-Ethyl-N-isopropyl)amiloride sensitive Na+ currents in intact fetal distal lung epithelial cells. | Wang, X., et al. 1993. Can J Physiol Pharmacol. 71: 58-62. PMID: 8390327
- Amiloride and 5-(N-ethyl-N-isopropyl) amiloride inhibit medium acidification and glucose metabolism by the fission yeast Schizosaccharomyces pombe. | Haworth, RS., et al. 1993. Biochim Biophys Acta. 1145: 266-72. PMID: 8431459
- 5-(N-Ethyl-N-isopropyl)-amiloride inhibits amino acid release from the ischemic rat cerebral cortex: role of Na+-H+ exchange. | Phillis, JW., et al. 1998. Brain Res. 812: 297-300. PMID: 9813378
Inhibitor of:
α-actinin-1, βENaC, AE4, ATP6V0E1, CCDC93, CHMP2B, CHP2, EG435376, EHBP1L1, EHD (EH Domain Containing), FCHO1, Hrs, KCC2b, MAMDC4, MVB12A, Na+ CP type III, Na+ CP type Vα, NCX2, NECAP 2, NEEP21, NHE, NHE-1, NHE-11, NHE-2, NHE-3, NHE-4, NHE-6, NHEDC2, Olfr438, Rab 11A, Rab 5A, Rab 5C, Rab GDI (GDP dissociation inhibitor), Rabex-5, SCARA5, SH3YL1, Sialin, sNHE, SNX17, SNX20, SNX26, SNX33, TBC1D5, TMEM168, TMEM200C, TMIE, UNQ830, VPS36, VPS37, VPS37C, and VPS8.Activator of:
γENaC, AE3, ATP6V0E2, C17orf59, Calnexin, CdcA7, CHMP4A, CHMP4B, CHP, Clca6, EEA1, EG625591, MANSC4, Maspardin, NECAP 1, NHE-2, NHE-9, NKAIN4, OTOP2, PCLN-1, Plb2, Rabaptin-5β, SGK, SNX17, SNX25, SNX32, TBC1D13, V-ATPase G1, VPS16, and VPS37B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-(N-Ethyl-N-isopropyl)-Amiloride, 5 mg | sc-202458 | 5 mg | $102.00 |