USP51 Activators
Ubiquitin Specific Peptidase 51 (USP51) is a relatively understudied member of the deubiquitinating enzyme family, playing a pivotal role in cellular processes such as DNA repair, cell cycle regulation, and chromatin remodeling. The intricacies of USP51's function are linked to its ability to bind chromatin and histones, suggesting a profound impact on the epigenetic regulation of gene expression. As a protein coding gene, USP51's expression patterns are not uniform across the body, with notable expression in the thyroid and ovary, alongside a broader presence across various other tissues. The regulation of USP51 expression is a complex orchestration of both genetic and epigenetic factors, and understanding the substances that can steer this regulation is crucial for comprehending its role in cellular homeostasis and responses to genomic stress.
A cohort of chemical compounds has been identified that could potentially stimulate the expression of USP51, acting as activators through diverse molecular pathways. Compounds such as Trichostatin A and Vorinostat, classified as histone deacetylase inhibitors, are known to open up the chromatin structure, thereby potentially enhancing the transcriptional activity of genes like USP51. On a different front, agents like 5-Azacytidine can induce hypomethylation of DNA, which might lead to the stimulation of USP51 expression by allowing transcriptional machinery greater access to its promoter region. Other compounds, including natural polyphenols like Resveratrol and Curcumin, are thought to activate a battery of stress response genes and could conceivably increase USP51 expression as part of the cell's adaptive response to oxidative stress and DNA damage. Moreover, signaling molecules such as Forskolin, which elevate cAMP levels, might indirectly lead to the upregulation of USP51 by initiating a cascade of transcriptional events aimed at maintaining cellular integrity in the face of various stressors. While the exact mechanisms by which these compounds induce USP51 expression remain to be fully elucidated, the potential role of these activators in modulating the USP51 pathway underscores the intricate network of genetic regulation within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may upregulate USP51 by inhibiting histone deacetylases, leading to an open chromatin conformation that enhances the transcription machinery's access to the USP51 gene, potentially resulting in increased mRNA synthesis and protein expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound could induce USP51 expression by causing the hypomethylation of DNA within the promoter region of the USP51 gene, thereby stimulating transcriptional activation in response to this epigenetic alteration. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid may stimulate USP51 expression by promoting the acetylation of histone proteins associated with the USP51 gene, enhancing transcriptional activity and potentially leading to elevated levels of the USP51 protein. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate could increase USP51 levels by inhibiting histone deacetylase activity, which would cause a more accessible chromatin structure around the USP51 gene locus, thereby facilitating transcriptional upregulation. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
By binding to estrogen receptors, β-Estradiol might stimulate the expression of USP51 as part of a signaling cascade that promotes the transcription of genes involved in DNA repair and chromatin remodeling, including USP51. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid could induce the transcription of USP51 by activating retinoic acid receptors that bind to regulatory regions of the USP51 gene, leading to an increase in gene expression in tissues where these receptors are expressed. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin might stimulate the production of cAMP, which could lead to the activation of transcription factors that enhance the expression of USP51, suggesting a role in the upregulation of genes associated with cellular stress responses, including DNA repair. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $36.00 $88.00 $220.00 $436.00 | 8 | |
By inhibiting DNA replication, L-Mimosine could stimulate a cellular stress response that includes the upregulation of USP51, potentially as a mechanism to enhance DNA repair capabilities. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin might induce the expression of USP51 through its role in activating cellular defense mechanisms against oxidative stress, which could include the upregulation of genes associated with the ubiquitin-proteasome system. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may stimulate USP51 expression by activating the SIRT1 pathway, which is known to be involved in the cellular response to DNA damage, potentially leading to enhanced transcription of DNA repair genes such as USP51. | ||||||