USP36 Activators
USP36 Activators are a class of compounds that enhance the functional activity of USP36 through direct or indirect interactions. For example, Forskolin, IBMX, BAY 60-6583, Anandamide, Dibutyryl cAMP, and Prostaglandin E2 all work through the cAMP-PKA pathway. They increase the intracellular cAMP levels, leading to the activation of PKA. PKA then phosphorylates proteins in USP36-related pathways, enhancing its functional activity. Other activators, like A23187 and Thapsigargin, act by increasing intracellular calcium levels, which can activate calcium-dependent kinases that phosphorylate proteins in USP36-related pathways.
Phorbol 12-myristate 13-acetate (PMA) and Chelerythrine chloride operate through the Protein Kinase C (PKC) pathway, altering the phosphorylation state of proteins related to USP36(continued from above) and thereby influencing its activity. Despite having opposing effects on PKC, both compounds can affect USP36 activity through their influence on the phosphorylation state of proteins within the same pathway. Genistein prevents the dephosphorylation of proteins within the pathways that USP36 operates within, thereby enhancing its activity. Lastly, L-NAME increases PKA activation and enhances phosphorylation of proteins in USP36-related pathways by reducing nitric oxide levels, a molecule known to inhibit PKA.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, resulting in an increase in intracellular cAMP levels. Elevated cAMP levels activate Protein Kinase A (PKA), which can phosphorylate proteins in the pathways that USP36 operates within, leading to enhanced functionality of USP36. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a phosphodiesterase inhibitor, which increases intracellular cAMP levels. The increase in cAMP activates PKA, leading to enhanced phosphorylation of proteins in the USP36-associated pathways, thereby increasing functional activity of USP36. | ||||||
BAY 60-6583 | 910487-58-0 | sc-503262 | 10 mg | $210.00 | ||
BAY 60-6583 is an A2B adenosine receptor agonist, which increases cAMP levels upon activation. Elevated cAMP levels lead to the activation of PKA, which enhances the phosphorylation of proteins in the pathways associated with USP36, consequently enhancing its function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular levels of calcium. Increased calcium levels can activate calcium-dependent kinases that phosphorylate proteins within the USP36-associated pathways, leading to enhanced activity of USP36. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cell-permeable analog of cAMP that can activate PKA, leading to enhanced phosphorylation of proteins in the USP36-related pathways, which in turn increases USP36 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC), which can phosphorylate proteins within USP36-related pathways, leading to enhanced activity of USP36. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine chloride is a potent, selective, and cell-permeable PKC inhibitor that influences the phosphorylation state of proteins within USP36-related pathways. The inhibition of PKC leads to altered phosphorylation state of these proteins, which can enhance USP36 activity. | ||||||
L-NG-Nitroarginine Methyl Ester (L-NAME) | 51298-62-5 | sc-200333 sc-200333A sc-200333B | 1 g 5 g 25 g | $47.00 $105.00 $322.00 | 45 | |
L-NAME is an inhibitor of nitric oxide synthase. By reducing nitric oxide levels, a molecule that can inhibit PKA, L-NAME can lead to increased PKA activation and enhanced phosphorylation of proteins in USP36-related pathways, thereby enhancing USP36 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can prevent the dephosphorylation of proteins within USP36-related pathways, maintaining their active phosphorylated state and enhancing USP36 activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 activates the prostaglandin E receptor, leading to increased cAMP levels. The increased cAMP activates PKA, which enhances the phosphorylation of proteins in USP36-related pathways, thereby increasing USP36 activity. | ||||||