USP24 Activators
USP24 Activators are a class of compounds that enhance the functional activity of USP24 through direct or indirect interactions. For instance, Forskolin, IBMX, BAY 60-6583, Anandamide, Dibutyryl cAMP, and Prostaglandin E2 all work through the cAMP-PKA pathway. They increase the intracellular cAMP levels, leading to the activation of PKA. PKA then phosphorylates proteins in USP24-related pathways, enhancing its functional activity. This class of compounds illustrates how alteration in cAMP levels can directly influence the functional activity of USP24.
Other activators like A23187 and Thapsigargin act by increasing intracellular calcium levels, which can activate calcium-dependent kinases that phosphorylate proteins in USP24-related pathways. Phorbol 12-myristate 13-acetate (PMA) and Chelerythrinechloride, on the other hand, influence the Protein Kinase C (PKC) pathway, altering the phosphorylation state of proteins related to USP24. L-NAME works by reducing nitric oxide levels, which can inhibit PKA, thereby increasing PKA activation and enhancing USP24 activity. Genistein, a tyrosine kinase inhibitor, prevents the dephosphorylation of proteins, maintaining their active state and enhancing USP24 activity. These compounds, while diverse in their biological functions, all converge on the common goal: the enhancement of USP24 functional activity by manipulating the cellular pathways it is involved in.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of the enzyme adenylate cyclase, increasing intracellular levels of cAMP. The elevated cAMP can activate Protein Kinase A (PKA), leading to enhanced phosphorylation of proteins in the pathways that USP24 operates in, thereby increasing its functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterase, an enzyme that degrades cAMP. This action increases cAMP levels, which can activate PKA, leading to enhanced phosphorylation of proteins in the USP24-related pathways and consequently enhancing its functional activity. | ||||||
BAY 60-6583 | 910487-58-0 | sc-503262 | 10 mg | $210.00 | ||
BAY 60-6583 is an A2B adenosine receptor agonist, which is known to increase cAMP levels upon activation. The increased cAMP activates PKA, enhancing the phosphorylation of proteins in USP24-related pathways and thus heightening USP24 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular levels of calcium. The increased calcium levels can trigger the activation of calcium-dependent kinases that phosphorylate proteins in USP24-related pathways, leading to enhanced USP24 activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog that can activate PKA due to its ability to mimic cAMP. This leads to enhanced phosphorylation of proteins in USP24-related pathways, in turn increasing USP24 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a known activator of protein kinase C (PKC), which can phosphorylate proteins in USP24-related pathways, leading to enhanced USP24 activity. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine chloride is a potent, selective, and cell-permeable protein kinase C inhibitor that alters the phosphorylation state of proteins in USP24-related pathways. The inhibition of PKC leads to altered phosphorylation state of these proteins, which can enhance USP24 activity. | ||||||
L-NG-Nitroarginine Methyl Ester (L-NAME) | 51298-62-5 | sc-200333 sc-200333A sc-200333B | 1 g 5 g 25 g | $47.00 $105.00 $322.00 | 45 | |
L-NAME is an inhibitor of nitric oxide synthase, reducing nitric oxide levels, a molecule that can inhibit PKA. Reduced nitric oxide levels can lead to increased PKA activation and enhanced phosphorylation of proteins in USP24-related pathways, thereby enhancing USP24 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can prevent the dephosphorylation of proteins in USP24-related pathways, maintaining their active phosphorylated state and enhancing USP24 activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 activates the prostaglandin E receptor, leading to elevated cAMP levels. The increased cAMP activates PKA, which enhances the phosphorylation of proteins in USP24-related pathways and in turn increases USP24 activity. | ||||||