USP24 Inhibitors
USP24 inhibitors comprise a range of chemicals predominantly targeting the deubiquitinating enzymes (DUBs) within the ubiquitin-proteasome system (UPS). Since USP24 is a member of the USP family of DUBs, broad-spectrum inhibitors such as PR-619, WP1130, and NSC 632839 can directly inhibit its enzymatic activity, subsequently affecting ubiquitin-regulated processes in the cell. These broad-acting inhibitors demonstrate the capacity to impede multiple DUBs, underscoring their influence on USP24 functionality.
On a more specific note, while compounds like ML323, P22077, HBX 41,108, and P5091 primarily target other USPs such as USP1 or USP7, their broader DUB inhibitory profiles suggest a to modulate USP24 activity. Additionally, chemicals like 15-Deoxy-Δ-12,14-prostaglandin J2 and Betulinic acid serve as natural inhibitors of USPs, and their interaction with the UPS can indirectly bear implications for USP24. Mitoxantrone and NMS-873, while not exclusively DUB inhibitors, influence proteasomal deubiquitinating activity, offering another layer of indirect regulation of USP24.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $75.00 $184.00 $423.00 | 1 | |
Broad-spectrum DUB inhibitor that can inhibit USP24 and other USPs. | ||||||
WP1130 | 856243-80-6 | sc-364650 sc-364650A | 10 mg 50 mg | $480.00 $1455.00 | 1 | |
Inhibits several DUBs, including USP24. By suppressing DUB activity, it can influence ubiquitin-proteasome processes. | ||||||
P22077 | 1247819-59-5 | sc-478536 | 10 mg | $162.00 | ||
Affects USP7 and potentially other USPs including USP24. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
Impacts ubiquitin-specific proteases and autophagy; its broad effect on DUBs can influence USP24. | ||||||
P005091 | 882257-11-6 | sc-478535 | 10 mg | $155.00 | ||
Specific for USP7 but may have broader inhibitory effects on other USPs, potentially affecting USP24. | ||||||
15-Deoxy-δ12,14-Prostaglandin J2 | 87893-55-8 | sc-201262 sc-201262A | 1 mg 5 mg | $138.00 $540.00 | 5 | |
This is a natural inhibitor of USPs, potentially affecting USP24 functionality. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
While primarily an antineoplastic agent, it can inhibit proteasomal deubiquitinating activity, potentially affecting USP24 indirectly. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Has been found to inhibit USP7, and can potentially impact USP24 and other DUBs. | ||||||
NMS-873 | 1418013-75-8 | sc-478803 | 5 mg | $300.00 | ||
Affects the proteasome-associated DUB activity and can influence USP24 indirectly. | ||||||
NSC 632839 hydrochloride | 157654-67-6 | sc-204138 sc-204138A | 10 mg 50 mg | $119.00 $465.00 | ||
A broad-spectrum DUB inhibitor which can inhibit the activity of USP24 among other USPs. | ||||||