Molecular structure of 15-Deoxy-δ12,14-Prostaglandin J2, CAS Number: 87893-55-8
15-Deoxy-δ12,14-Prostaglandin J2 (CAS 87893-55-8)
See product citations (5)
Alternate Names:
15-Deoxy-δ12,14-Prostaglandin J2 is also known as 15D-PGJ2.
Application:
15-Deoxy-δ12,14-Prostaglandin J2 is an endogenous PPARγ ligand and ANKTM1 (TRPA1) agonist
CAS Number:
87893-55-8
Purity:
≥97%
Molecular Weight:
316.43
Molecular Formula:
C20H28O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
15-Deoxy-δ12,14-Prostaglandin J2 is heavily utilized in biochemical research for its role as a natural ligand of peroxisome proliferator-activated receptor gamma (PPARγ). This involvement makes it a critical compound for studying metabolic regulation and cellular differentiation processes. Research on 15-Deoxy-δ12,14-Prostaglandin J2 often focuses on its effects in modulating adipogenesis and its potential role in regulating inflammatory gene expression. Moreover, this compound is studied for its influence on the nuclear factor-kappa B (NF-κB) signaling pathway, which plays a significant part in immune response and inflammation. Additionally, due to its anti-inflammatory properties, 15-Deoxy-δ12,14-Prostaglandin J2 is employed in research aimed at understanding mechanisms of inflammation resolution.
15-Deoxy-δ12,14-Prostaglandin J2 (CAS 87893-55-8) References
- Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2. | Bishop-Bailey, D. and Hla, T. 1999. J Biol Chem. 274: 17042-8. PMID: 10358055
- Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. | Tsubouchi, Y., et al. 2000. Biochem Biophys Res Commun. 270: 400-5. PMID: 10753637
- 15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. | Kawahito, Y., et al. 2000. J Clin Invest. 106: 189-97. PMID: 10903334
- 15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells. | Clay, CE., et al. 2002. J Lipid Res. 43: 1818-28. PMID: 12401880
- 15d-PGJ2: the anti-inflammatory prostaglandin? | Scher, JU. and Pillinger, MH. 2005. Clin Immunol. 114: 100-9. PMID: 15639643
- Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury. | Genovese, T., et al. 2005. Eur Respir J. 25: 225-34. PMID: 15684285
- 15-deoxy-Delta12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors. | Kim, EH. and Surh, YJ. 2006. Biochem Pharmacol. 72: 1516-28. PMID: 16987499
- The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. | Vunta, H., et al. 2007. J Biol Chem. 282: 17964-17973. PMID: 17439952
- Modification and activation of Ras proteins by electrophilic prostanoids with different structure are site-selective. | Renedo, M., et al. 2007. Biochemistry. 46: 6607-16. PMID: 17489560
- Activation of TRPA1 by farnesyl thiosalicylic acid. | Maher, M., et al. 2008. Mol Pharmacol. 73: 1225-34. PMID: 18171730
- Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2. | Kansanen, E., et al. 2009. Free Radic Biol Med. 47: 1310-7. PMID: 19573595
- 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. | Forman, BM., et al. 1995. Cell. 83: 803-12. PMID: 8521497
- A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. | Kliewer, SA., et al. 1995. Cell. 83: 813-9. PMID: 8521498
- The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. | Ricote, M., et al. 1998. Nature. 391: 79-82. PMID: 9422508
- PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. | Jiang, C., et al. 1998. Nature. 391: 82-6. PMID: 9422509
Inhibitor of:
HSP 60, OPA1, Peroxin 5, TSG-6, USP24, USP36, and ZNF727.Activator of:
ANKTM1, C7orf50, Calnexin, CC10, CRP, D630042P16Rik, DP2_CRTH2, EG627009, EG627094, ERGIC-3, Gab 2, GP49A, group VI iPLA2, HSP 40, IL-1RAcP, KLHL32, LANCL1, LARP4, Peroxin 16, PPAR gamma, RBM10, resistin, Rtn-2, and SCARA5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15-Deoxy-δ12,14-Prostaglandin J2, 1 mg | sc-201262 | 1 mg | $141.00 | |||
15-Deoxy-δ12,14-Prostaglandin J2, 5 mg | sc-201262A | 5 mg | $551.00 |