USP22 Activators
USP22 (Ubiquitin-Specific Protease 22) is involved in the regulation of protein stability and function through deubiquitination. While direct chemical activators of USP22 are rare, its expression and activity can be influenced indirectly by compounds affecting cellular signaling pathways, gene expression, and chromatin remodeling. Histone deacetylase inhibitors like Trichostatin A, Vorinostat, and Sodium butyrate can modulate chromatin structure and influence gene expression, affecting the expression of genes including USP22. These compounds can lead to changes in chromatin accessibility, thereby impacting gene regulation.
Curcumin, Resveratrol, and Epigallocatechin gallate (EGCG) are polyphenolic compounds known to modulate various signaling pathways and gene expression, which could extend to influencing USP22. Their effects on cellular signaling might indirectly affect the expression or function of USP22. 5-Azacytidine, a DNA methyltransferase inhibitor, can lead to the demethylation and activation of certain genes, impacting the expression of USP22. Niclosamide, known for its inhibitory effect on the Wnt/β-catenin signaling pathway, may also influence USP22, given the pathway's broad role in cellular processes. Betulinic acid and Disulfiram could impact signaling pathways involving USP22. PD98059, a MEK inhibitor, and SP600125, a JNK inhibitor, can affect cellular signaling pathways, impacting USP22 expression or activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor; can modulate chromatin structure and gene expression, potentially influencing USP22. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Another histone deacetylase inhibitor; might affect the expression of genes including USP22. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Known to modulate numerous signaling pathways, potentially affecting USP22 expression or function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Affects gene expression and signaling pathways, potentially impacting USP22. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol that can modulate various signaling pathways, potentially influencing USP22. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor; can lead to the demethylation of genes, possibly including USP22. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
A histone deacetylase inhibitor; might influence chromatin remodeling and affect USP22 expression. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
An antiparasitic that can inhibit Wnt/β-catenin signaling, potentially affecting USP22. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Known for its therapeutic potential in cancer; might impact signaling pathways involving USP22. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
An ALDH inhibitor; known for its role in cancer therapy, potentially impacting USP22. | ||||||