USP20 Activators
The USP20 (Ubiquitin Specific Peptidase 20) enzyme, belonging to the ubiquitin-proteasome system, has caught the attention of many researchers due to its intriguing roles within the cellular milieu. Its primary function is as a deubiquitinating enzyme (DUB), responsible for removing ubiquitin tags from target proteins. The process of ubiquitination serves as a cellular sorting mechanism, determining the fate of proteins. When a protein is tagged with ubiquitin, it can be slated for degradation, relocalized within the cell, or see its activity modulated. Thus, enzymes like USP20 that remove these tags can significantly influence protein lifespan and function, impacting numerous cellular processes.
USP20 activators are chemical entities that enhance the enzymatic activity of USP20. Their mode of action may be direct, such as by binding to the enzyme and promoting its catalytic function, or indirect, through pathways that upregulate the enzyme or maintain it in an active state. Being able to influence the activity of USP20 can have ripple effects on cellular protein management. For instance, by increasing USP20 activity, certain proteins might avoid degradation and persist longer within the cell, or potentially regain their original function after being ubiquitinated. As the field of ubiquitin biology expands, the understanding of these activators and their intricate interplay within cellular systems will undoubtedly become more refined.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol found in red wine and various plants, is known to modulate several signaling pathways. Its potential role in inducing USP20 could be linked to its ability to activate sirtuins, which are involved in cellular stress response and longevity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, the main active compound of turmeric, has anti-inflammatory properties. It may influence USP20 expression by modulating NF-κB signaling and other inflammation-associated pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid found in fruits and vegetables, may impact USP20 expression through its antioxidative properties and its ability to modulate various cellular signaling cascades. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a soy isoflavone. It could influence USP20 expression by modulating estrogen receptor signaling and other pathways relevant to cell proliferation and stress response. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, sulforaphane is known for its antioxidative properties. It might induce USP20 expression by activating NRF2, a key transcription factor in cellular defense mechanisms. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a vitamin A metabolite, is involved in cell differentiation. Its potential influence on USP20 might be linked to its role in gene expression modulation and cellular differentiation processes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methylation inhibitor. By altering DNA methylation patterns, it might influence the transcription of various genes, including USP20. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, elevating cAMP levels in cells. This can lead to the activation of PKA and subsequent modulation of various gene expressions, potentially including USP20. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid. It can influence various gene expressions, potentially including USP20, through its interaction with glucocorticoid receptors and the modulation of NF-κB signaling. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone, a PPARγ agonist, is involved in insulin sensitization. It might induce USP20 expression by modulating peroxisome proliferator-activated receptor gamma (PPARγ) signaling pathways. | ||||||