USP17L3 Activators
Ubiquitin Specific Peptidase 17 Like Family Member 3 (USP17L3) is a member of the ubiquitin-specific protease (USP) family, which is part of the larger cysteine protease enzyme group. Proteases in this family are known to be deubiquitinating enzymes (DUBs) that cleave ubiquitin moieties from ubiquitin-conjugated protein substrates. The process of deubiquitination is critical for the regulation of protein turnover and signaling, as it rescues proteins from being targeted for degradation by the proteasome, a cellular complex responsible for breaking down unwanted or damaged proteins.
USP17L3, like other members of the USP17 subfamily, is thought to play a role in the regulation of cellular processes such as cell cycle control, apoptosis, and signal transduction. This is achieved by modulating the stability and function of various substrate proteins through the removal of ubiquitin chains. The specificity of USP17L3 for particular substrates and the exact pathways it influences are areas of active research, as is the case with many DUBs.The activity of USP17L3 is tightly regulated within the cell, as uncontrolled deubiquitination can lead to aberrant cell signaling and contribute to disease states, including cancer and neurodegenerative disorders. The expression of USP17L3 may be regulated at both the transcriptional and post-translational levels, ensuring that its deubiquitinating activity is modulated according to cellular needs.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor which can lead to a relaxed chromatin structure and potentially increase the transcription of USP17L3 by allowing transcription factor access to the gene promoter. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor which may lead to demethylation of the USP17L3 gene promoter, potentially enhancing its transcription. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C which can modulate transcription factors that enhance USP17L3 gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, acting through retinoic acid receptors, can induce gene expression changes, possibly including upregulation of USP17L3 expression. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin elevates intracellular calcium levels, which may activate signaling pathways leading to the induction of USP17L3 expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin induces ER stress which can lead to the activation of the unfolded protein response, potentially increasing USP17L3 expression as part of the cellular stress response. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as a histone deacetylase inhibitor which can lead to hyperacetylation of histones and potentially induce USP17L3 expression by affecting chromatin accessibility. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases cAMP levels which can lead to the activation of cAMP response element-binding protein (CREB) and potentially enhance USP17L3 gene transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG has been shown to affect gene expression profiles, potentially including the induction of USP17L3 through modulation of signaling pathways that affect gene transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3), which may lead to the stabilization of transcription factors that enhance USP17L3 expression. | ||||||