UNC5H3 Activators
UNC5H3 Activators encompass a range of chemical compounds that indirectly enhance the functional activity of UNC5H3 through distinct signaling pathways and cellular processes. Forskolin, Isoproterenol, and N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate (db-cAMP) amplify intracellular cyclic AMP (cAMP) levels, leading to the activation of protein kinase A (PKA), which may subsequently phosphorylate substrates that promote UNC5H3 mediated functions in cellular adhesion and migration. Similarly, Ionomycin, by increasing intracellular calcium concentrations, could activate calcium-dependent signaling cascades that support UNC5H3's role in cell signaling. The tyrosine kinase inhibitory action of Epigallocatechin gallate (EGCG) may lessen competitive signaling, potentially making UNC5H3 pathways more predominant, thereby indirectly boosting its activity. Furthermore, Retinoic acid, by influencing gene expression patterns during neuronal development, might create a cellular context conducive to the activation of UNC5H3's pathways.
In addition to these, the pharmacological agents Rolipram, Nocodazole, and Cytochalasin D, by modulating cAMP levels, microtubule dynamics, and actin polymerization respectively, may indirectly elevate UNC5H3 activity by impacting the cellular infrastructure and signaling milieu in which UNC5H3 operates. Phorbol 12-myristate 13-acetate (PMA) as a protein kinase C (PKC) activator and Anisomycin, a stress-activated protein kinase (SAPK) activator, could both affect signaling pathways that interplay with those regulated by UNC5H3, leading to enhanced functionality of UNC5H3 in its various roles, including cell adhesion, migration, and apoptosis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which can lead to the activation of protein kinase A (PKA). PKA can phosphorylate proteins involved in the regulation of cell adhesion and migration, potentially enhancing the activity of UNC5H3 by promoting its mediated signaling pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels in cells, thereby activating PKA. The activation of PKA could enhance the phosphorylation state of proteins associated with UNC5H3 signaling, indirectly enhancing its functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration, which can activate calcium-dependent signaling pathways. This elevation in calcium levels might enhance the activity of UNC5H3 by modulating the downstream pathways it influences. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a tyrosine kinase inhibitor that could reduce competitive signaling pathways, potentially allowing UNC5H3-mediated signaling to be more prominent, thus indirectly enhancing UNC5H3 activity in processes like cell adhesion and migration. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid regulates gene expression through retinoic acid receptors and can influence neuronal development. It may enhance the activity of UNC5H3 by modulating the cellular environment and signaling pathways relevant to UNC5H3's role in axon guidance. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine is a polyamine that can modulate ion channel activity and cellular signaling. Its effects on cellular signaling may indirectly enhance the functional activity of UNC5H3 by modifying the intracellular environment where UNC5H3 signaling takes place. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which increases cAMP levels in the cell. Elevated cAMP could potentially enhance the activity of UNC5H3 through PKA activation and subsequent phosphorylation of associated proteins. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which can lead to changes in cell morphology and adhesion. These changes could indirectly enhance UNC5H3 activity by influencing cellular processes where UNC5H3 plays a role. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D inhibits actin polymerization, affecting cell shape and motility. This could indirectly enhance UNC5H3 activity by altering the cytoskeletal dynamics and cell adhesion processes that UNC5H3 is involved in. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC) that can modulate numerous signaling pathways. Activation of PKC may indirectly enhance UNC5H3 activity by influencing the signaling cascades that affect cell adhesion and migration. | ||||||