ULBP5 Activators
ULBP5 activators encompass a range of chemical compounds that have a unifying role in enhancing the functional activity of ULBP5 through indirect pathways, primarily by upregulating the expression of NKG2D ligands, thus facilitating immune recognition by NK cells. Sodium butyrate and valproic acid, both HDAC inhibitors, can lead to increased expression of NKG2D ligands including ULBP5 on the surface of cells. This increased expression is crucial for the activation of NK cells, as it enhances their ability to recognize and respond to abnormal cells. Similarly, immune response modifiers such as imiquimod and immune stimulants like IFN-gamma directly lead to the upregulation of ULBP5, potentiating the immune surveillance mechanism. Other compounds such as resveratrol and curcumin exert their effects on the immune system and have been reported to increase the expression of NKG2D ligands. This increase can enhance the activity of ULBP5 by making target cells more susceptible to NK cell-mediated cytolysis. Agents like Poly I:C mimic viral infection, leading to an enhanced immune response that includes the overexpression of ULBP5. This overexpression serves as a signal for NK cells to initiate an immune attack.
Agents such as 5-Fluorouracil inadvertently increase the expression of NKG2D ligands, such as ULBP5, on cancer cells, rendering them more vulnerable to immune cell targeting. Epigenetic modulators like azacytidine reverse the silencing of gene expression, which includes NKG2D ligands, thereby facilitating the increased functional activity of ULBP5. Lastly, immunomodulatory drugs such as lenalidomide enhance the immune response against abnormal cells by upregulating the expression of ULBP5, thereby providing an effective signal for NK cell-mediated cytotoxicity. Each of these compounds, through their unique interactions with cellular pathways, contributes to the enhanced activity of ULBP5, ensuring robust immune surveillance and response.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a short-chain fatty acid, serves as an HDAC inhibitor which can upregulate the expression of NKG2D ligands on tumor cells, thereby potentially enhancing the functional activity of ULBP5 by increasing its recognition by NK cells. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod is an immune response modifier that can lead to increased expression of NKG2D ligands such as ULBP5 on various cells, enhancing their susceptibility to NK cell-mediated cytotoxicity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can modulate immune responses and has been shown to upregulate NKG2D ligands in cancer cells. This could enhance the activation of ULBP5 by increasing its presentation to NK cells. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 modulates the immune system and has been reported to increase the expression of NKG2D ligands, which might enhance the functional activity of ULBP5 on cells by promoting immune recognition and response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has immunomodulatory effects and has been shown to increase the expression of NKG2D ligands, potentially enhancing ULBP5 activity by making cells more visible to NK cell recognition. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Poly I:C, a synthetic analog of double-stranded RNA, acts as a potent immune stimulant that can enhance the expression of NKG2D ligands, which might lead to an increased functional activity of ULBP5. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil, a chemotherapeutic agent, has been observed to upregulate NKG2D ligands in certain cancer cells, which could enhance the functional activity of ULBP5 by improving immune recognition. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is an HDAC inhibitor that can increase the surface expression of NKG2D ligands such as ULBP5, leading to enhanced recognition and elimination of abnormal cells by NK cells. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Azacytidine acts as a DNA methyltransferase inhibitor, leading to the upregulation of genes including those encoding NKG2D ligands, potentially increasing the functional activity of ULBP5 by enhancing immune detection. | ||||||
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $50.00 $374.00 $2071.00 | 18 | |
Lenalidomide has been shown to increase the expression of NKG2D ligands on the surface of certain cancer cells, which could in turn enhance the functional activity of ULBP5 by promoting NK cell-mediated cytotoxicity. | ||||||