UGT2B37 Activators
Chemical activators of UGT2B37 include a variety of compounds that engage with different cellular pathways to enhance the functional activity of this detoxification enzyme. Sulforaphane, for instance, is a potent activator of the Nrf2 pathway, a crucial regulator in the cellular defense against oxidative stress. Upon activation, Nrf2 translocates to the nucleus where it binds to antioxidant response elements (ARE) in the promoter regions of target genes, including those encoding for UGT enzymes like UGT2B37. The binding results in increased transcription and subsequent elevation in enzyme activity, facilitating the conjugation of various substrates with glucuronic acid, a process known as glucuronidation. Similarly, compounds such as oltipraz, diallyl sulfide, ellagic acid, tert-butylhydroquinone, and zerumbone also activate the Nrf2 pathway, leading to the upregulation of UGT2B37.
Another pathway implicated in the activation of UGT2B37 is mediated through the aryl hydrocarbon receptor (AhR). Chemicals like 3-methylcholanthrene and indole-3-carbinol can bind to AhR, which upon activation, translocates to the nucleus and dimerizes with the ARNT (AhR nuclear translocator) protein. The AhR/ARNT complex then binds to xenobiotic response elements (XRE) in the promoter regions of genes coding for metabolic enzymes, including UGT2B37. This binding enhances the transcription of UGT2B37, thereby augmenting its enzymatic activity. In a different pathway, phenobarbital activates the constitutive androstane receptor (CAR), which can then promote the expression and activity of UGT2B37. Similarly, chrysin and clofibric acid, through the activation of peroxisome proliferator-activated receptors (PPARs), can lead to the activation of UGT2B37 by influencing the transcription of genes involved in lipid and xenobiotic metabolism. Resveratrol's activation of SIRT1 affects various metabolic pathways and can enhance the activity of UGT2B37, though the exact mechanism remains more indirect compared to other pathways mentioned.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which in turn can upregulate the expression of detoxification enzymes including UGTs such as UGT2B37, leading to enhanced glucuronidation activity. | ||||||
3-Methylcholanthrene | 56-49-5 | sc-252030 sc-252030A | 100 mg 250 mg | $388.00 $831.00 | 2 | |
3-Methylcholanthrene is known to activate the AhR (Aryl hydrocarbon receptor) pathway, which increases the transcription of various xenobiotic-processing enzymes, including UGTs like UGT2B37, by binding to xenobiotic response elements in their promoters. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz activates the Nrf2 pathway, which can then induce the expression of phase II detoxification enzymes such as UGT2B37, resulting in its functional activation. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Chrysin has been reported to activate peroxisome proliferator-activated receptors (PPARs), which may lead to the activation of UGT2B37, as PPARs regulate the transcription of various metabolic enzymes. | ||||||
Clofibric acid | 882-09-7 | sc-203000 sc-203000A | 10 g 50 g | $24.00 $40.00 | 1 | |
Clofibric acid, a PPAR alpha agonist, can activate PPAR-mediated pathways that may lead to upregulation and functional activation of UGT2B37 involved in lipid metabolism. | ||||||
Diallyl sulfide | 592-88-1 | sc-204718 sc-204718A | 25 g 100 g | $42.00 $106.00 | 3 | |
Diallyl sulfide can activate Nrf2, leading to an indirect activation of UGT2B37 by enhancing the transcription of detoxifying enzymes including UGTs. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid is known to activate the Nrf2 pathway, which may lead to increased expression and functional activation of phase II detoxification enzymes including UGT2B37. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol can activate AhR, which then upregulates the expression of enzymes like UGT2B37 that are involved in the metabolism of endogenous and exogenous substances. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can activate SIRT1 which is implicated in the regulation of various metabolic pathways, potentially leading to the functional activation of UGT2B37. | ||||||
t-Butylhydroquinone | 1948-33-0 | sc-202825 | 10 g | $67.00 | 4 | |
Tert-butylhydroquinone (tBHQ) can activate the Nrf2 pathway, subsequently leading to the functional activation of phase II detoxifying enzymes like UGT2B37. | ||||||