Molecular structure of Clofibric acid, CAS Number: 882-09-7
Clofibric acid (CAS 882-09-7)
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Application:
Clofibric acid is a hypolipidemic compound
CAS Number:
882-09-7
Purity:
≥98%
Molecular Weight:
214.65
Molecular Formula:
C10H11ClO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Clofibric acid is a compound that reduces cholesterol levels in blood through diminishing the activity of NADPH. In vitro experiments have demonstrated that its mode of action is to competitively inhibit NADPH by effecting the rate of substrate synthesis and substrate affinity. The compounds effects are also attributed to activation of PPARα and weak activation of both PPARγ and PPARδ.
Clofibric acid (CAS 882-09-7) References
- Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats. | Lupp, A., et al. 2008. Arzneimittelforschung. 58: 225-41. PMID: 18589557
- Additive effects of clofibric acid and pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) deficiency on hepatic steatosis in mice fed a high saturated fat diet. | Hwang, B., et al. 2012. FEBS J. 279: 1883-93. PMID: 22429297
- Biodegradation of clofibric acid and identification of its metabolites. | Salgado, R., et al. 2012. J Hazard Mater. 241-242: 182-9. PMID: 23062606
- Mechanism for enhanced degradation of clofibric acid in aqueous by catalytic ozonation over MnOx/SBA-15. | Sun, Q., et al. 2015. J Hazard Mater. 286: 276-84. PMID: 25590821
- Clofibric acid and gemfibrozil removal in membrane bioreactors. | Gutierrez-Macias, T. and Nacheva, PM. 2015. Water Sci Technol. 71: 1143-50. PMID: 25909723
- Metabolism of clofibric acid in zebrafish embryos (Danio rerio) as determined by liquid chromatography-high resolution-mass spectrometry. | Brox, S., et al. 2016. Comp Biochem Physiol C Toxicol Pharmacol. 185-186: 20-28. PMID: 26945519
- Photocatalytic degradation of clofibric acid by g-C3N4/P25 composites under simulated sunlight irradiation: The significant effects of reactive species. | Chen, P., et al. 2017. Chemosphere. 172: 193-200. PMID: 28068571
- Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle. | Meffin, PJ., et al. 1983. J Pharmacol Exp Ther. 227: 732-8. PMID: 6655566
- Clofibric acid, phenylpyruvate, and dichloroacetate inhibition of branched-chain alpha-ketoacid dehydrogenase kinase in vitro and in perfused rat heart. | Paxton, R. and Harris, RA. 1984. Arch Biochem Biophys. 231: 58-66. PMID: 6721502
- Mode of action of the lipid-lowering agents, clofibrate and BM 15075, on cholesterol biosynthesis in rat liver. | Berndt, J., et al. 1978. Atherosclerosis. 30: 147-52. PMID: 678316
- Mechanism of action of fibrates. | Shepherd, J. 1993. Postgrad Med J. 69 Suppl 1: S34-41. PMID: 8497455
- Clofibric acid increases the undirectional chiral inversion of ibuprofen in rat liver preparations. | Roy-de Vos, M., et al. 1996. Xenobiotica. 26: 571-82. PMID: 8810029
- Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. | Forman, BM., et al. 1997. Proc Natl Acad Sci U S A. 94: 4312-7. PMID: 9113986
Inhibitor of:
ACOX1, ADK, CLC-2, CLC-4, CLC-KB, CLCA2, CLIC5, LRRC8C, SULT2A6, and UGT1A9.Activator of:
ACCSL, CYP4V3, LRRC8E, NKG2-D, Peroxin 5, PPAR alpha, UGT1A1, UGT1A5, UGT1A6, UGT1A6A, UGT1A6B, UGT2A1, UGT2A2, and UGT2B37.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clofibric acid, 10 g | sc-203000 | 10 g | $24.00 | |||
Clofibric acid, 50 g | sc-203000A | 50 g | $40.00 |