UGT1A6 Inhibitors
UGT1A6 inhibitors are a class of chemical compounds that specifically target and modulate the activity of the enzyme UDP-glucuronosyltransferase 1A6 (UGT1A6). UDP-glucuronosyltransferases are a family of enzymes involved in the phase II metabolism of xenobiotics, including drugs, toxins, and endogenous compounds. UGT1A6 is one of the isoforms within this family, primarily found in the liver and some extrahepatic tissues, and it plays a crucial role in the detoxification and elimination of various substances from the body. Inhibition of UGT1A6 can have significant implications for drug metabolism and pharmacokinetics, as it can lead to altered drug concentrations and drug-drug interactions.
UGT1A6 inhibitors can act by binding to the active site of the enzyme, preventing its catalytic function. This inhibition may result in reduced glucuronidation of substrates, leading to their prolonged presence in the body and increased toxicity. Understanding and developing UGT1A6 inhibitors is important in the field of pharmacology and drug development because it can help researchers predict and manage drug interactions and adverse effects. Additionally, these inhibitors can be used as tools in studies to investigate the role of UGT1A6 in the metabolism of specific drugs or xenobiotics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Atazanavir | 198904-31-3 | sc-207305 | 5 mg | $292.00 | 7 | |
Atazanavir may decrease UGT1A6 expression by interacting with regulatory elements of the gene that controls its expression. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $66.00 $267.00 | 2 | |
Gemfibrozil can inhibit UGT1A6 expression likely through interference with nuclear receptors that regulate the transcription of the UGT1A6 gene. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin might suppress UGT1A6 expression by modulating the signaling pathways that are involved in the gene expression at a transcriptional level. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine is known to inhibit various drug-metabolizing enzymes, including UGTs, potentially by binding to the enzyme or the gene's regulatory regions. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin, a potent inducer of some UGTs, has been shown to inhibit others, possibly through competitive binding or downregulation of expression. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib can modulate the expression of various enzymes and transporters, potentially including UGT1A6, by altering transcription factor activity. | ||||||
Ethynyl Estradiol | 57-63-6 | sc-205318 sc-205318A | 100 mg 500 mg | $20.00 $29.00 | 3 | |
Ethinyl Estradiol can inhibit UGT1A6 expression possibly by estrogen receptor-mediated alteration of the gene transcription process. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole is known to affect cytochrome P450 enzymes and could similarly affect UGTs by altering the intracellular environment that regulates these enzymes. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Chrysin is a flavonoid that can affect the expression of various enzymes involved in metabolism, possibly by influencing gene regulatory mechanisms. | ||||||