UGT1A6 Antibody (C-12): sc-514913

UGT1A6 Antibody (C-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects UGT1A6 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UGT1A6 Antibody (C-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. UGT1A6 is a member of the UDP-glucuronosyltransferase (UGT) superfamily, which is crucial for glucuronidation, a key metabolic pathway that facilitates the detoxification and elimination of bile acids, drugs, and other xenobiotics from the body. UGT1A6 is predominantly located in the liver, where UGT1A6 plays a vital role in drug metabolism and the regulation of endogenous compounds, thereby influencing hormonal balance and energy metabolism. UGT1A6 is known to interact with various nuclear receptors, such as pregnane X receptor (PXR) and constitutive androstane receptor (CAR), which modulate UGT1A6 expression and activity in response to different physiological and pathological conditions. Understanding the function and regulation of UGT1A6 is essential, as deficiencies in UGT1A6 can lead to serious metabolic disorders, including Crigler-Najjar syndrome and Gilbert syndrome, highlighting UGT1A6′s importance in maintaining metabolic homeostasis and preventing the accumulation of potentially harmful substances in the body.

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UGT1A6 Antibody (C-12) References:

1. Chromosomal assignment of human phenol and bilirubin UDP-glucuronosyltransferase genes (UGT1A-subfamily).  |  Moghrabi, N., et al. 1992. Ann Hum Genet. 56: 81-91. PMID: 1503396
2. Comparative genomics analysis of human sequence variation in the UGT1A gene cluster.  |  Maitland, ML., et al. 2006. Pharmacogenomics J. 6: 52-62. PMID: 16314881
3. Monospecific antipeptide antibodies against human hepatic UDP-glucuronosyltransferase 1A subfamily (UGT1A) isoforms.  |  Ikushiro, S., et al. 2006. Drug Metab Pharmacokinet. 21: 70-4. PMID: 16547396
4. Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin.  |  Han, JY., et al. 2006. J Clin Oncol. 24: 2237-44. PMID: 16636344
5. Genetic variability, haplotypes, and htSNPs for exons 1 at the human UGT1A locus.  |  Thomas, SS., et al. 2006. Hum Mutat. 27: 717. PMID: 16786511
6. The UGT1A6_19_GG genotype is a breast cancer risk factor.  |  Justenhoven, C., et al. 2013. Front Genet. 4: 104. PMID: 23781229
7. UGT1A6- and UGT2B7-related valproic acid pharmacogenomics according to age groups and total drug concentration levels.  |  Chatzistefanidis, D., et al. 2016. Pharmacogenomics. 17: 827-35. PMID: 27232006
8. UGT1A6 and UGT2B7 Gene Polymorphism and its Effect in Pediatric Epileptic Patients on Sodium Valproate Monotherapy.  |  Nandith, PB., et al. 2021. Indian J Pediatr. 88: 764-770. PMID: 33400134
9. Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma.  |  Matsumoto, J., et al. 2023. Mol Cell Biochem. 478: 1779-1790. PMID: 36571650
10. Genetic defects at the UGT1 locus associated with Crigler-Najjar type I disease, including a prenatal diagnosis.  |  Ciotti, M., et al. 1997. Am J Med Genet. 68: 173-8. PMID: 9028453
11. The novel UGT1 gene complex links bilirubin, xenobiotics, and therapeutic drug metabolism by encoding UDP-glucuronosyltransferase isozymes with a common carboxyl terminus.  |  Owens, IS., et al. 1996. J Pharmacokinet Biopharm. 24: 491-508. PMID: 9131487
12. Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer.  |  Strassburg, CP., et al. 1997. Cancer Res. 57: 2979-85. PMID: 9230212

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UGT1A6 Antibody (C-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-UGT1A6 Antibody (C-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UGT1A6 Antibody (C-12) Specifications

Alternate Product Name: UGT1A6

Product Clone Name: C-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 81-176

Epitope Target: UGT1A6

Epitope Species: human

Product Reactivity/Detection: UGT1A6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for UGT1A6 Antibody (C-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred UGT1A antibody is UGT1A Antibody (B-4): sc-271268.